Association of Testosterone and Sex Hormone–Binding Globulin With Metabolic Syndrome and Insulin Resistance in Men

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Li, Chaoyang ; Ford, Earl S. ; Li, Benyi ; Giles, Wayne H. ; Liu, Simin
• Description:
  OBJECTIVE ; We sought to assess the associations of testosterones and sex hormone–binding globulin (SHBG) with metabolic syndrome and insulin resistance in men. ; RESEARCH DESIGN AND METHODS ; We defined metabolic syndrome according to the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Among men aged ≥20 years who participated in the Third National Health and Nutrition Examination Survey (n = 1,226), the Cox proportional hazards model was used to estimate the prevalence ratio and 95% CI of metabolic syndrome according to circulating concentrations of testosterones and SHBG. ; RESULTS ; After adjustment for age, race/ethnicity, smoking status, alcohol intake, physical activity level, LDL cholesterol, C-reactive protein, and insulin resistance, men in the first quartile (lowest) (prevalence ratio 2.16 95% CI 1.53–3.06) and second quartile of total testosterone (2.51 1.86–3.37) were more likely to have metabolic syndrome than men in the fourth quartile (highest, referent group) (P < 0.001 for linear trend). Similarly, men in the first quartile of SHBG (2.17 1.32–3.56) were more likely to have metabolic syndrome than men in the fourth quartile (P = 0.02 for linear trend). No significant associations of calculated free testosterone (P = 0.31 for linear trend) and bioavailable testosterone (P = 0.11 for linear trend) with metabolic syndrome were detected after adjustment for all possible confounders. ; CONCLUSIONS ; Low concentrations of total testosterone and SHBG were strongly associated with increased likelihood of having metabolic syndrome, independent of traditional cardiovascular risk factors and insulin resistance.
• Subjects:
  • Adult
  • Biological Markers
  • Fasting
  • Homeostasis
  • Humans
  • Insulin Resistance
  • Life Style
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  More +
• Source:
  Diabetes Care. 33(7):1618-1624.
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  33
• Issue:
  7
• Download URL:
  https://stacks.cdc.gov/view/cdc/4398/cdc_4398_DS1.pdf
• File Type:
  [PDF - 305.16 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e3364b1e90ee3840a44f1eb854385e0ea0f20b4424256fac2bfd516cacb47663