RIG-I ligand enhances the immunogenicity of recombinant H7 HA protein

Details

• Alternative Title:
  Cell Immunol
• Personal Author:
  Cao, Weiping ; Liepkalns, Justine S. ; Kamal, Ram P. ; Reber, Adrian J. ; Kim, Jin Hyang ; Hofstetter, Amelia R. ; Amoah, Samuel ; Stevens, James ; Ranjan, Priya ; Gangappa, Shivaprakash ; York, Ian A. ; Sambhara, Suryaprakash
• Description:
  Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
• Subjects:
  Adjuvants, Immunologic Animals Cells, Cultured DEAD Box Protein 58 Female Hemagglutinin Glycoproteins, Influenza Virus Humans Immunity, Humoral Influenza, Human Influenza A Virus, H7N9 Subtype Influenza Vaccines Lymphocyte Activation Mice Mice, Inbred BALB C Orthomyxoviridae Infections Receptors, Immunologic Receptors, Pattern Recognition T-Lymphocytes Vaccines, Synthetic

  More +
• Source:
  Cell Immunol. 304-305:55-58
• Pubmed ID:
  27106062
• Pubmed Central ID:
  PMC5240151
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7bed73dbcec0d9cc633d466930bbb672d09f1bc45bf9e42ad36241890e75f9b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/43863/cdc_43863_DS1.pdf
• File Type:
  [PDF - 960.70 KB ]