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RIG-I ligand enhances the immunogenicity of recombinant H7 HA protein
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  1. Effect of receptor binding specificity on the immunogenicity and protective efficacy of influenza virus A H1 vaccines
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    Sun, Xiangjie; Cao, Weiping; Pappas, Claudia; Liu, Feng; Katz, Jacqueline M.; Tumpey, Terrence M.;
    Published Date:
    July 30 2014
    Source:
    Virology. 464-465:156-165
    Description:
    The biological basis for the poor immunogenicity of unadjuvanted avian influenza A virus vaccines in mammals is not well understood. Here, we mutated the hemagglutinin (HA) of two H1N1 virus vaccines to determine whether virus receptor binding specif...
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  2. H5N1 pathogenesis studies in mammalian models
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    Belser, Jessica A.; Tumpey, Terrence M.;
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    Feb 28 2013
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    Virus Res. 178(1):168-185.
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    H5N1 influenza viruses are capable of causing severe disease and death in humans, and represent a potential pandemic subtype should they acquire a transmissible phenotype. Due to the expanding host and geographic range of this virus subtype, there is...
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  3. Crimean-Congo Hemorrhagic Fever Virus suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease
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    Scholte, Florine E.M.; Zivcec, Marko; Dzimianski, John V.; Deaton, Michelle K.; Spengler, Jessica R.; Welch, Stephen R.; Nichol, Stuart T.; Pegan, Scott D.; Spiropoulou, Christina F.; Bergeron, Éric;
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    Sep 05 2017
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    Cell Rep. 20(10):2396-2407
    Description:
    Antiviral responses are regulated by conjugation of ubiquitin (Ub) and interferon-stimulated gene 15 (ISG15) to proteins. Certain classes of viruses encode Ub- or ISG15-specific proteases belonging to the ovarian tumor (OTU) superfamily. Their activi...
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    Personal Author:
    Kamal, Ram P.; Katz, Jaqueline M.; York, Ian A.;
    Published Date:
    2014
    Source:
    Curr Top Microbiol Immunol. 385:243-274.
    Description:
    Mice are widely used for studying influenza virus pathogenesis and immunology because of their low cost, the wide availability of mouse-specific reagents, and the large number of mouse strains available, including knockout and transgenic strains. How...
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  5. Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice
    Personal Author:
    Liu, Feng; Liang, Mifang; Cao, Shouchun; Liu, Qinzhi; Zhang, Quanfu; Li, Chuan; Zhang, Shuo; Wang, Shiwen; Li, Dexin;
    Published Date:
    Sep 23 2011
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    Virol J. 2011; 8:448.
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    BackgroundHantaan virus (HTNV) is the causative agent of the most severe form of a rodent-borne disease known as hemorrhagic fever with renal syndrome (HFRS). A safe and effective HTNV vaccine is needed. Vaccination with DNA constructs expressing fus...
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