RIG-I ligand enhances the immunogenicity of recombinant H7 HA protein

Cao, Weiping; Liepkalns, Justine S.; Kamal, Ram P.; Reber, Adrian J.; Kim, Jin Hyang; Hofstetter, Amelia R.; Amoah, Samuel; Stevens, James; Ranjan, Priya; Gangappa, Shivaprakash; York, Ian A.; Sambhara, Suryaprakash

doi:10.1016/j.cellimm.2016.04.004

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RIG-I ligand enhances the immunogenicity of recombinant H7 HA protein

2016
By Cao, Weiping ; Liepkalns, Justine S. ; Kamal, Ram P. ; ...
http://dx.doi.org/10.1016/j.cellimm.2016.04.004
Source: Cell Immunol. 304-305:55-58

[PDF-960.70 KB]

English

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Details:

Alternative Title:

Cell Immunol
Personal Author:

Cao, Weiping ; Liepkalns, Justine S. ; Kamal, Ram P. ; Reber, Adrian J. ; Kim, Jin Hyang ; ... More +

Cao, Weiping ; Liepkalns, Justine S. ; Kamal, Ram P. ; Reber, Adrian J. ; Kim, Jin Hyang ; Hofstetter, Amelia R. ; Amoah, Samuel ; Stevens, James ; Ranjan, Priya ; Gangappa, Shivaprakash ; York, Ian A. ; Sambhara, Suryaprakash Less -
Description:

Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
Subjects:

[+]

Adjuvants, Immunologic Animals Cells, Cultured DEAD Box Protein 58 Female Hemagglutinin Glycoproteins, Influenza Virus Humans Immunity, Humoral Influenza, Human Influenza A Virus, H7N9 Subtype Influenza Vaccines Lymphocyte Activation Mice Mice, Inbred BALB C Orthomyxoviridae Infections Receptors, Immunologic Receptors, Pattern Recognition T-Lymphocytes Vaccines, Synthetic
Source:

Cell Immunol. 304-305:55-58
Pubmed ID:

27106062
Pubmed Central ID:

PMC5240151
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:7bed73dbcec0d9cc633d466930bbb672d09f1bc45bf9e42ad36241890e75f9b2
Download URL:

https://stacks.cdc.gov/view/cdc/43863/cdc_43863_DS1.pdf
File Type:

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