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RIG-I ligand enhances the immunogenicity of recombinant H7 HA protein
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2016
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Source: Cell Immunol. 304-305:55-58
[PDF-960.70 KB]
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Alternative Title:Cell Immunol
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Description:Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
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Pubmed ID:27106062
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Pubmed Central ID:PMC5240151
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