Details:

Alternative Title:
Cell Immunol
Publisher's site:
http://dx.doi.org/10.1016/j.cellimm.2016.04.004
Personal Author:
Cao, Weiping; Liepkalns, Justine S.; Kamal, Ram P.; Reber, Adrian J.; Kim, Jin Hyang; ... More +
Cao, Weiping; Liepkalns, Justine S.; Kamal, Ram P.; Reber, Adrian J.; Kim, Jin Hyang; Hofstetter, Amelia R.; Amoah, Samuel; Stevens, James; Ranjan, Priya; Gangappa, Shivaprakash; York, Ian A.; Sambhara, Suryaprakash; Less -
Description:
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
Subject:
[+]
Adjuvants, Immunologic
Animals
Antibody Responses
Article
Cell-mediated Immunity
Cells, Cultured
DEAD Box Protein 58
Female
H7HA
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Immunity, Humoral
Influenza
Influenza, Human
Influenza A Virus, H7N9 Subtype
Influenza Vaccines
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Mouse Model
Orthomyxoviridae Infections
Protective Immunity
Receptors, Pattern Recognition
RIG-I Ligand
T-Lymphocytes
Vaccines, Synthetic

Source:
Cell Immunol. 304-305:55-58.;
Pubmed ID:
27106062
Pubmed Central ID:
PMC5240151
Document Type:
Journal Article;
Funding:
CC999999/Intramural CDC HHS/United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7bed73dbcec0d9cc633d466930bbb672d09f1bc45bf9e42ad36241890e75f9b2
File Type:

Supporting Files

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