Details:

Alternative Title:
PLoS Pathog
Personal Author:
Towner, Jonathan S.; Amman, Brian R.; Sealy, Tara K.; Carroll, Serena A. Reeder; Comer, James A.; ... More +
Towner, Jonathan S.; Amman, Brian R.; Sealy, Tara K.; Carroll, Serena A. Reeder; Comer, James A.; Kemp, Alan; Swanepoel, Robert; Paddock, Christopher D.; Balinandi, Stephen; Khristova, Marina L.; Formenty, Pierre B. H.; Albarino, Cesar G.; Miller, David M.; Reed, Zachary D.; Kayiwa, John T.; Mills, James N.; Cannon, Deborah L.; Greer, Patricia W.; Byaruhanga, Emmanuel; Farnon, Eileen C.; Atimnedi, Patrick; Okware, Samuel; Katongole-Mbidde, Edward; Downing, Robert; Tappero, Jordan W.; Zaki, Sherif R.; Ksiazek, Thomas G.; Nichol, Stuart T.; Rollin, Pierre E.; Less -
Description:
In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat sera, and isolation of genetically diverse virus from bat tissues. The virus isolates were collected nine months apart, demonstrating long-term virus circulation. The bat colony was estimated to be over 100,000 animals using mark and re-capture methods, predicting the presence of over 5,000 virus-infected bats. The genetically diverse virus genome sequences from bats and miners closely matched. These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans.
Subject:
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Animals
Antibodies, Viral
Antigens, Viral
Chiroptera
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunohistochemistry
Liver
Male
Marburgvirus
Marburg Virus Disease
Phylogeny
Reverse Transcriptase Polymerase Chain Reaction

Source:
PLoS Pathog. 2009; 5(7);
Pubmed ID:
19649327
Pubmed Central ID:
PMC2713404
Document Type:
Journal Article;
Place as Subject:
Uganda;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4bcd5297011448a0e55080cbe8c46c5497be292c03a54c1e4c45e49ed23647ce
File Type:

Supporting Files

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  	ppat.1000536.s001.doc	doc
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