Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats

Towner, Jonathan S.; Amman, Brian R.; Sealy, Tara K.; Carroll, Serena A. Reeder; Comer, James A.; Kemp, Alan; Swanepoel, Robert; Paddock, Christopher D.; Balinandi, Stephen; Khristova, Marina L.; Formenty, Pierre B. H.; Albarino, Cesar G.; Miller, David M.; Reed, Zachary D.; Kayiwa, John T.; Mills, James N.; Cannon, Deborah L.; Greer, Patricia W.; Byaruhanga, Emmanuel; Farnon, Eileen C.; Atimnedi, Patrick; Okware, Samuel; Katongole-Mbidde, Edward; Downing, Robert; Tappero, Jordan W.; Zaki, Sherif R.; Ksiazek, Thomas G.; Nichol, Stuart T.; Rollin, Pierre E.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats

Published Date:

Jul 31 2009

Source:

PLoS Pathog. 5(7).

[PDF-341.74 KB]

Details:

Personal Authors:

Towner, Jonathan S. ; Amman, Brian R. ; Sealy, Tara K. ; Carroll, Serena A. Reeder ; Comer, James A. ; ... More ▼

Keywords:

[+]

Description:

In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat sera, and isolation of genetically diverse virus from bat tissues. The virus isolates were collected nine months apart, demonstrating long-term virus circulation. The bat colony was estimated to be over 100,000 animals using mark and re-capture methods, predicting the presence of over 5,000 virus-infected bats. The genetically diverse virus genome sequences from bats and miners closely matched. These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	ppat.1000536.t001.jpg	image/jpeg
	ppat.1000536.t002.gif	image/gif
	ppat.1000536.t002.jpg	image/jpeg
	ppat.1000536.t003.gif	image/gif
	ppat.1000536.t003.jpg	image/jpeg
	license.txt	text/plain
	ppat.1000536.g001.gif	image/gif
	ppat.1000536.g001.jpg	image/jpeg
	ppat.1000536.g002.gif	image/gif
	ppat.1000536.g002.jpg	image/jpeg
	ppat.1000536.nxml	text/plain
	ppat.1000536.s001.doc	application/msword
	ppat.1000536.t001.gif	image/gif

No Related Documents.

You May Also Like:

Marburgvirus in Egyptian Fruit Bats, Zambia

Personal Author:

Kajihara, Masahiro; Hang’ombe, Bernard M.; Changula, Katendi; Harima, Hayato; Isono, Mao; Okuya, Kosuke; Yoshida, Reiko; Mori-Kajihara, Akina; Eto, Yoshiki; Orba, Yasuko; Ogawa, Hirohito; Qiu, Yongjin; Sawa, Hirofumi; Simulundu, Edgar; Mwizabi, Daniel; Munyeme, Musso; Squarre, David; Mukonka, Victor; Mweene, Aaron; Takada, Ayato;

Published:

August 17 2019

Source:

Emerg Infect Dis. 25(8):1577-1580

Description:

We detected Marburg virus genome in Egyptian fruit bats (Rousettus aegyptiacus) captured in Zambia in September 2018. The virus was closely related phylogenetically to the viruses that previously caused Marburg outbreaks in the Democratic Republic of...

File Type:

[PDF - 854.42 KB]
Filoviruses and bats

Personal Author:

Schuh, Amy J; Amman, Brian R; Towner, Jonathan S;

Published:

Feb 17 2017

Source:

. 38(1):12-16.

Description:

While Reston and Lloviu viruses have never been associated with human disease, the other filoviruses cause outbreaks of hemorrhagic fever characterised by person-to-person transmission and high case fatality ratios. Cumulative evidence suggests that ...

File Type:

[PDF - 286.31 KB]
Marburg Virus Infection in Egyptian Rousette Bats, South Africa, 2013–20141

Personal Author:

Pawęska, Janusz T.; Jansen van Vuren, Petrus; Kemp, Alan; Storm, Nadia; Grobbelaar, Antoinette A.; Wiley, Michael R.; Palacios, Gustavo; Markotter, Wanda;

Published:

Jun 2018

Source:

Emerg Infect Dis. 24(6):1134-1137.

Description:

We detected a high seroprevalence of Marburg virus (MARV) antibodies in fruit bats in South Africa; 19.1% of recaptured bats seroconverted. The MARV RNA isolated closely resembled the 1975 Ozolin strain. These findings indicate endemic MARV circulati...

File Type:

[PDF - 602.39 KB]
Genetically Diverse Filoviruses in Rousettus and Eonycteris spp. Bats, China, 2009 and 2015

Personal Author:

Yang, Xing-Lou; Zhang, Yun-Zhi; Jiang, Ren-Di; Guo, Hua; Zhang, Wei; Li, Bei; Wang, Ning; Wang, Li; Waruhiu, Cecilia; Zhou, Ji-Hua; Li, Shi-Yue; Daszak, Peter; Wang, Lin-Fa; Shi, Zheng-Li;

Published:

Mar 2017

Source:

Emerg Infect Dis. 23(3):482-486.

Description:

Genetically divergent filoviruses detected in Rousettus and Eonycteris spp. bats in China exhibited 61%-99% nt identity with reported filoviruses, based on partial replicase sequences, and they demonstrated lung tropism. Co-infection with 4 different...

File Type:

[PDF - 1.66 MB]
No evidence for the involvement of the argasid tick Ornithodoros faini in the enzootic maintenance of marburgvirus within Egyptian rousette bats Rousettus aegyptiacus

Personal Author:

Schuh, Amy J.; Amman, Brian R.; Apanaskevich, Dmitry A.; Sealy, Tara K.; Nichol, Stuart T.; Towner, Jonathan S.;

Published:

Mar 05 2016

Source:

Parasit Vectors. 9.

Description:

Background : The cave-dwelling Egyptian rousette bat (ERB; Rousettus aegyptiacus) was recently identified as a natural reservoir host of marburgviruses. However, the mechanisms of transmission for the enzootic maintenance of marburgviruses within ERB...

File Type:

[PDF - 399.08 KB]