Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Quan, Phenix-Lan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

Published Date:

Nov 21 2008

Source:

PLoS Pathog. 2008; 4(11).

[PDF-281.02 KB]

Details:

Personal Authors:

Towner, Jonathan S. ; Sealy, Tara K. ; Khristova, Marina L. ; Albariño, César G. ; Conlan, Sean ; ... More ▼

Keywords:

[+]

Description:

Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Supporting Files:

license.txt	text/plain
ppat.1000212.g001.gif	image/gif
ppat.1000212.g001.jpg	image/jpeg
ppat.1000212.nxml	text/plain
ppat.1000212.t001.gif	image/gif
ppat.1000212.t001.jpg	image/jpeg
ppat.1000212.t002.gif	image/gif
ppat.1000212.t002.jpg	image/jpeg

No Related Documents.

You May Also Like:

Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda

Personal Author:

MacNeil, Adam; Farnon, Eileen C.; Wamala, Joseph; Okware, Sam; Cannon, Deborah L.; Reed, Zachary; Towner, Jonathan S.; Tappero, Jordan W.; Lutwama, Julius; Downing, Robert; Nichol, Stuart T.; Ksiazek, Thomas G.; Rollin, Pierre E.;

Published:

Dec 2010

Source:

Emerg Infect Dis. 16(12):1969-1972.

Description:

The first known Ebola hemorrhagic fever (EHF) outbreak caused by Bundibugyo Ebola virus occurred in Bundibugyo District, Uganda, in 2007. Fifty-six cases of EHF were laboratory confirmed. Although signs and symptoms were largely nonspecific and simil...

File Type:

[PDF - 340.54 KB]
Reemerging Sudan Ebola Virus Disease in Uganda, 2011

Personal Author:

Shoemaker, Trevor; MacNeil, Adam; Balinandi, Stephen; Campbell, Shelley; Wamala, Joseph Francis; McMullan, Laura K.; Downing, Robert; Lutwama, Julius; Mbidde, Edward; Ströher, Ute; Rollin, Pierre E.; Nichol, Stuart T.;

Published:

Sep 2012

Source:

Emerg Infect Dis. 18(9):1480-1483.

Description:

Two large outbreaks of Ebola hemorrhagic fever occurred in Uganda in 2000 and 2007. In May 2011, we identified a single case of Sudan Ebola virus disease in Luwero District. The establishment of a permanent in-country laboratory and cooperation betwe...

File Type:

[PDF - 392.03 KB]
Filoviruses and bats

Personal Author:

Schuh, Amy J; Amman, Brian R; Towner, Jonathan S;

Published:

Feb 17 2017

Source:

. 38(1):12-16.

Description:

While Reston and Lloviu viruses have never been associated with human disease, the other filoviruses cause outbreaks of hemorrhagic fever characterised by person-to-person transmission and high case fatality ratios. Cumulative evidence suggests that ...

Public Access
Available on:

March 01, 2018
Emerging Filoviral Disease in Uganda: Proposed Explanations and Research Directions

Personal Author:

Polonsky, Jonathan A.; Wamala, Joseph F.; de Clerck, Hilde; Van Herp, Michel; Sprecher, Armand; Porten, Klaudia; Shoemaker, Trevor;

Published:

Feb 10 2014

Source:

Am J Trop Med Hyg. 2014; 90(5):790-793.

Description:

Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency in Uganda. This increase is probably caused by a combination of improved surveillance and laboratory capacity, increased contact between humans and the natural reservo...

File Type:

[PDF - 324.32 KB]
Incubation Period of Ebola Hemorrhagic Virus Subtype Zaire

Personal Author:

Eichner, Martin; Dowell, Scott F.; Firese, Nina;

Published:

Apr 12 2011

Source:

Osong Public Health Res Perspect. 2011; 2(1):3-7.

Description:

Objectives : Ebola hemorrhagic fever has killed over 1300 people, mostly in equatorial Africa. There is still uncertainty about the natural reservoir of the virus and about some of the factors involved in disease transmission. Until now, a maximum in...

File Type:

[PDF - 164.60 KB]