Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Quan, Phenix-Lan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

Published Date:

Nov 21 2008

Source:

PLoS Pathog. 2008; 4(11).

[PDF-281.02 KB]

Details:

Alternative Title:

PLoS Pathog

Personal Author:

Towner, Jonathan S. ; Sealy, Tara K. ; Khristova, Marina L. ; Albariño, César G. ; Conlan, Sean ; ... More ▼

Description:

Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.

Subject:

[+]

Document Type:

Journal Article

Place as Subject:

Uganda

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	license.txt	text/plain
	ppat.1000212.g001.gif	image/gif
	ppat.1000212.g001.jpg	image/jpeg
	ppat.1000212.nxml	text/plain
	ppat.1000212.t001.gif	image/gif
	ppat.1000212.t001.jpg	image/jpeg
	ppat.1000212.t002.gif	image/gif
	ppat.1000212.t002.jpg	image/jpeg

No Related Documents.

You May Also Like:

Risk factors for hematemesis in Hoima and Buliisa Districts, Western Uganda, September-October 2015

Personal Author:

Kabwama, Steven Ndugwa; Mafigiri, Richardson; Balinandi, Stephen; Kagirita, Atek; Riolexus, Alex Ario; Zhu, Bao-Ping;

Published Date:

November 08 2017

Source:

Pan Afr Med J. 2017; 28

Description:

IntroductionOn 17 September 2015, Buliisa District Health Office reported multiple deaths due to haemorrhage to the Uganda Ministry of Health. We conducted an investigation to verify the existence of an outbreak and to identify the disease nature, mo...

File Type:

[PDF - 434.96 KB]
Proportion of Deaths and Clinical Features in Bundibugyo Ebola Virus Infection, Uganda

Personal Author:

MacNeil, Adam; Farnon, Eileen C.; Wamala, Joseph; Okware, Sam; Cannon, Deborah L.; Reed, Zachary; Towner, Jonathan S.; Tappero, Jordan W.; Lutwama, Julius; Downing, Robert; Nichol, Stuart T.; Ksiazek, Thomas G.; Rollin, Pierre E.;

Published Date:

Dec 2010

Source:

Emerg Infect Dis. 16(12):1969-1972.

Description:

The first known Ebola hemorrhagic fever (EHF) outbreak caused by Bundibugyo Ebola virus occurred in Bundibugyo District, Uganda, in 2007. Fifty-six cases of EHF were laboratory confirmed. Although signs and symptoms were largely nonspecific and simil...

File Type:

[PDF - 340.54 KB]
Reemerging Sudan Ebola Virus Disease in Uganda, 2011

Personal Author:

Shoemaker, Trevor; MacNeil, Adam; Balinandi, Stephen; Campbell, Shelley; Wamala, Joseph Francis; McMullan, Laura K.; Downing, Robert; Lutwama, Julius; Mbidde, Edward; Ströher, Ute; Rollin, Pierre E.; Nichol, Stuart T.;

Published Date:

Sep 2012

Source:

Emerg Infect Dis. 18(9):1480-1483.

Description:

Two large outbreaks of Ebola hemorrhagic fever occurred in Uganda in 2000 and 2007. In May 2011, we identified a single case of Sudan Ebola virus disease in Luwero District. The establishment of a permanent in-country laboratory and cooperation betwe...

File Type:

[PDF - 392.03 KB]
Filoviruses and bats

Personal Author:

Schuh, Amy J; Amman, Brian R; Towner, Jonathan S;

Published Date:

Feb 17 2017

Source:

. 38(1):12-16.

Description:

While Reston and Lloviu viruses have never been associated with human disease, the other filoviruses cause outbreaks of hemorrhagic fever characterised by person-to-person transmission and high case fatality ratios. Cumulative evidence suggests that ...

File Type:

[PDF - 286.31 KB]
Emerging Filoviral Disease in Uganda: Proposed Explanations and Research Directions

Personal Author:

Polonsky, Jonathan A.; Wamala, Joseph F.; de Clerck, Hilde; Van Herp, Michel; Sprecher, Armand; Porten, Klaudia; Shoemaker, Trevor;

Published Date:

Feb 10 2014

Source:

Am J Trop Med Hyg. 2014; 90(5):790-793.

Description:

Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency in Uganda. This increase is probably caused by a combination of improved surveillance and laboratory capacity, increased contact between humans and the natural reservo...

File Type:

[PDF - 324.32 KB]