Details:

Alternative Title:
PLoS Pathog
Personal Author:
Towner, Jonathan S. ; Sealy, Tara K. ; Khristova, Marina L. ; Albariño, César G. ; Conlan, Sean ; ... More +
Towner, Jonathan S. ; Sealy, Tara K. ; Khristova, Marina L. ; Albariño, César G. ; Conlan, Sean ; Reeder, Serena A. ; Quan, Phenix-Lan ; Lipkin, W. Ian ; Downing, Robert ; Tappero, Jordan W. ; Okware, Samuel ; Lutwama, Julius ; Bakamutumaho, Barnabas ; Kayiwa, John ; Comer, James A. ; Rollin, Pierre E. ; Ksiazek, Thomas G. ; Nichol, Stuart T. ; Less -
Description:
Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Western Uganda. Laboratory investigation of the initial 29 suspect-case blood specimens by classic methods (antigen capture, IgM and IgG ELISA) and a recently developed random-primed pyrosequencing approach quickly identified this to be an Ebola HF outbreak associated with a newly discovered ebolavirus species (Bundibugyo ebolavirus) distantly related to the Côte d'Ivoire ebolavirus found in western Africa. Due to the sequence divergence of this new virus relative to all previously recognized ebolaviruses, these findings have important implications for design of future diagnostic assays to monitor Ebola HF disease in humans and animals, and ongoing efforts to develop effective antivirals and vaccines.
Subject:
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Antigens, Viral
Base Sequence
Disease Outbreaks
Ebolavirus
Enzyme-Linked Immunosorbent Assay
Hemorrhagic Fever, Ebola
Humans
RNA, Viral

Source:
PLoS Pathog. 2008 ; 4(11).;
Document Type:
Journal Article ;
Place as Subject:
Uganda ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:dfc0718bb86823686940ec36b2adc367576a4954efc572824d2a54eaf99e037f
File Type:

Supporting Files

• 	license.txt	txt
  	ppat.1000212.g001.gif	gif
  	ppat.1000212.g001.jpg	jpeg
  	ppat.1000212.nxml	txt
  	ppat.1000212.t001.gif	gif
  	ppat.1000212.t001.jpg	jpeg
  	ppat.1000212.t002.gif	gif
  	ppat.1000212.t002.jpg	jpeg

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