The gut microbiota in conventional and serrated precursors of colorectal cancer

Details

• Alternative Title:
  Microbiome
• Personal Author:
  Peters, Brandilyn A. ; Dominianni, Christine ; Shapiro, Jean A. ; Church, Timothy R. ; Wu, Jing ; Miller, George ; Yuen, Elizabeth ; Freiman, Hal ; Lustbader, Ian ; Salik, James ; Friedlander, Charles ; Hayes, Richard B. ; Ahn, Jiyoung
• Description:
  Background
  
  Colorectal cancer is a heterogeneous disease arising from at least two precursors—the conventional adenoma (CA) and the serrated polyp. We and others have previously shown a relationship between the human gut microbiota and colorectal cancer; however, its relationship to the different early precursors of colorectal cancer is understudied. We tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types.
  
  Results
  
  Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Participants were categorized as CA cases (n = 144), serrated polyp cases (n = 73), or polyp-free controls (n = 323). CA cases were further classified as proximal (n = 87) or distal (n = 55) and as non-advanced (n = 121) or advanced (n = 22). Serrated polyp cases were further classified as hyperplastic polyp (HP; n = 40) or sessile serrated adenoma (SSA; n = 33). We compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups.
  
  Conclusions
  
  Our results indicate that gut microbes may play a role in the early stages of colorectal carcinogenesis through the development of CAs. Findings may have implications for developing colorectal cancer prevention therapies targeting early microbial drivers of colorectal carcinogenesis.
  
  Electronic supplementary material
  
  The online version of this article (doi:10.1186/s40168-016-0218-6) contains supplementary material, which is available to authorized users.
  
  
• Subjects:
  Adenoma Aged Bacteria Base Sequence Cancer Colonic Polyps Colonoscopy Colorectal Colorectal Neoplasms DNA, Bacterial Feces Female Gastrointestinal Microbiome Humans Hyperplasia Male Mass Screening Microbiome Microbiota Middle Aged Polyp Research Sequence Analysis, DNA Serrated

  More +
• Source:
  Microbiome. 4.
• Pubmed ID:
  28038683
• Pubmed Central ID:
  PMC5203720
• Document Type:
  Journal Article
• Funding:
  R01 CA159036/CA/NCI NIH HHS/United States ; P30 CA016087/CA/NCI NIH HHS/United States ; P30 ES000260/ES/NIEHS NIH HHS/United States ; R21 CA183887/CA/NCI NIH HHS/United States ; R03 CA159414/CA/NCI NIH HHS/United States ; U01 CA182370/CA/NCI NIH HHS/United States ; R01 CA164964/CA/NCI NIH HHS/United States
• Volume:
  4
• NIOSHTIC Number:
  nn:20064562
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19501d527aee809d6611a84d2cd7f43c3f3ef65e9e330cb346b236f09442b5a6172c52eb05991703aa5a2c8da9b5ddb6d478335a0ff1b1a4b069a87ad30ed4f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/43645/cdc_43645_DS1.pdf
• File Type:
  [PDF - 3.72 MB ]