Health Related Quality of Life among Patients with Tuberculosis and HIV in Thailand

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Kittikraisak, Wanitchaya ; Kingkaew, Pritaporn ; Teerawattananon, Yot ; Yothasamut, Jomkwan ; Natesuwan, Supalert ; Manosuthi, Weerawat ; Chongsuvivatwong, Virasakdi ; Whitehead, Sara J.
• Description:
  Introduction
  
  Health utilities of tuberculosis (TB) patients may be diminished by side effects from medication, prolonged treatment duration, physical effects of the disease itself, and social stigma attached to the disease.
  
  Methods
  
  We collected health utility data from Thai patients who were on TB treatment or had been successfully treated for TB for the purpose of economic modeling. Structured questionnaire and EuroQol (EQ-5D) and EuroQol visual analog scale (EQ-VAS) instruments were used as data collection tools. We compared utility of patients with two co-morbidities calculated using multiplicative model (UCAL) with the direct measures and fitted Tobit regression models to examine factors predictive of health utility and to assess difference in health utilities of patients in various medical conditions.
  
  Results
  
  Of 222 patients analyzed, 138 (62%) were male; median age at enrollment was 40 years (interquartile range [IQR], 35–47). Median monthly household income was 6,000 Baht (187 US$; IQR, 4,000–15,000 Baht [125–469 US$]). Concordance correlation coefficient between utilities measured using EQ-5D and EQ-VAS (UEQ-5D and UVAS, respectively) was 0.6. UCAL for HIV-infected TB patients was statistically different from the measured UEQ-5D (p-value<0.01) and UVAS (p-value<0.01). In tobit regression analysis, factors independently predictive of UEQ-5D included age and monthly household income. Patients aged ≥40 years old rated UEQ-5D significantly lower than younger persons. Higher UEQ-5D was significantly associated with higher monthly household income in a dose response fashion. The median UEQ-5D was highest among patients who had been successfully treated for TB and lowest among multi-drug resistant TB (MDR-TB) patients who were on treatment.
  
  Conclusions
  
  UCAL of patients with two co-morbidities overestimated the measured utilities, warranting further research of how best to estimate utilities of patients with such conditions. TB and MDR-TB treatments impacted on patients' self perceived health status. This effect diminished after successful treatment.
  
  
• Subjects:
  Adult Demography Female Health Health Status Indicators HIV Infections Humans Male Middle Aged Models, Biological Multivariate Analysis Pain Measurement Quality Of Life Questionnaires Regression Analysis Tuberculosis

  More +
• Source:
  PLoS One. 2012; 7(1).
• Document Type:
  Journal Article
• Place as Subject:
  Thailand
• Volume:
  7
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bb02c16cdf85857e5dbd791bf8c51df37abd97cee42f1df78e2ff59dac523928
• Download URL:
  https://stacks.cdc.gov/view/cdc/4361/cdc_4361_DS1.pdf
• File Type:
  [PDF - 233.70 KB ]