Proteome complexity and the forces that drive proteome imbalance

Details

• Alternative Title:
  Nature
• Personal Author:
  Harper, J. Wade ; Bennett, Eric J.
• Description:
  The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.
• Subjects:
  Animals Article Autophagy Chromosome Aberrations Gene Dosage Homeostasis Humans Multiprotein Complexes Neoplasms Protein Biosynthesis Protein Transport Proteome Ribosomes

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• Source:
  Nature. 537(7620):328-338
• Pubmed ID:
  27629639
• Pubmed Central ID:
  PMC5204264
• Document Type:
  Journal Article
• Funding:
  GM095567/GM/NIGMS NIH HHS/United States ; R37NS083524/NS/NINDS NIH HHS/United States ; AG011085/AG/NIA NIH HHS/United States ; R37 NS083524/NS/NINDS NIH HHS/United States ; 1DP2GM119132/DP/NCCDPHP CDC HHS/United States ; R01 GM095567/GM/NIGMS NIH HHS/United States ; R01 AG011085/AG/NIA NIH HHS/United States ; DP2 GM119132/GM/NIGMS NIH HHS/United States ; 2P50GM085764/GM/NIGMS NIH HHS/United States ; P50 GM085764/GM/NIGMS NIH HHS/United States
• Volume:
  537
• Issue:
  7620
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eddf3c08ac90467716d9ca38504b916f73fe954351617ff5bbd1315424b54982
• Download URL:
  https://stacks.cdc.gov/view/cdc/43581/cdc_43581_DS1.pdf
• File Type:
  [PDF - 1.68 MB ]