Welcome to CDC stacks | Proteome complexity and the forces that drive proteome imbalance - 43581 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Proteome complexity and the forces that drive proteome imbalance
Filetype[PDF-1.68 MB]


Details:
  • Pubmed ID:
    27629639
  • Pubmed Central ID:
    PMC5204264
  • Description:
    The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.

  • Document Type:
  • Collection(s):
  • Funding:
    GM095567/GM/NIGMS NIH HHS/United States
    R37NS083524/NS/NINDS NIH HHS/United States
    AG011085/AG/NIA NIH HHS/United States
    R37 NS083524/NS/NINDS NIH HHS/United States
    1DP2GM119132/DP/NCCDPHP CDC HHS/United States
    R01 GM095567/GM/NIGMS NIH HHS/United States
    R01 AG011085/AG/NIA NIH HHS/United States
    DP2 GM119132/GM/NIGMS NIH HHS/United States
    2P50GM085764/GM/NIGMS NIH HHS/United States
    P50 GM085764/GM/NIGMS NIH HHS/United States
No Related Documents.
You May Also Like: