Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Marks, Michael ; Mitjà, Oriol ; Fitzpatrick, Christopher ; Asiedu, Kingsley ; Solomon, Anthony W. ; ... More +
Marks, Michael ; Mitjà, Oriol ; Fitzpatrick, Christopher ; Asiedu, Kingsley ; Solomon, Anthony W. ; Mabey, David C.W. ; Funk, Sebastian Less -
Description:
Yaws is targeted for eradication by 2020. The mainstay of the eradication strategy is mass treatment followed by case finding. Modeling has been used to inform programmatic requirements for other neglected tropical diseases and could provide insights into yaws eradication. We developed a model of yaws transmission varying the coverage and number of rounds of treatment. The estimated number of cases arising from an index case (basic reproduction number [R0]) ranged from 1.08 to 3.32. To have 80% probability of achieving eradication, 8 rounds of treatment with 80% coverage were required at low estimates of R0 (1.45). This requirement increased to 95% at high estimates of R0 (2.47). Extending the treatment interval to 12 months increased requirements at all estimates of R0. At high estimates of R0 with 12 monthly rounds of treatment, no combination of variables achieved eradication. Models should be used to guide the scale-up of yaws eradication.
Subjects:
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Anti-Bacterial Agents Azithromycin Computer Simulation Disease Eradication Female Humans Male Markov Chains Models, Statistical Neglected Diseases/prevention & Control Recurrence Treponema Pallidum Tropical Climate Yaws
Source:
Emerg Infect Dis. 23(1):22-28.
Pubmed ID:
27983500
Pubmed Central ID:
PMC5176210
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:4c2018c670ec4ae7ee35762861eaf76e60486954db083ebaa322f4125303fe78
Download URL:
https://stacks.cdc.gov/view/cdc/43519/cdc_43519_DS1.pdf
File Type:

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