Mathematical Modeling of Programmatic Requirements for Yaws Eradication

Marks, Michael; Mitjà, Oriol; Fitzpatrick, Christopher; Asiedu, Kingsley; Solomon, Anthony W.; Mabey, David C.W.; Funk, Sebastian

doi:10.3201/eid2301.160487

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Mathematical Modeling of Programmatic Requirements for Yaws Eradication

Published Date:

Jan 2017

Publisher's site:

http://dx.doi.org/10.3201/eid2301.160487 New Site Icon

Source:

Emerg Infect Dis. 23(1):22-28.

[PDF-930.48 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Marks, Michael ; Mitjà, Oriol ; Fitzpatrick, Christopher ; Asiedu, Kingsley ; Solomon, Anthony W. ; ... More ▼

Description:

Yaws is targeted for eradication by 2020. The mainstay of the eradication strategy is mass treatment followed by case finding. Modeling has been used to inform programmatic requirements for other neglected tropical diseases and could provide insights into yaws eradication. We developed a model of yaws transmission varying the coverage and number of rounds of treatment. The estimated number of cases arising from an index case (basic reproduction number [R0]) ranged from 1.08 to 3.32. To have 80% probability of achieving eradication, 8 rounds of treatment with 80% coverage were required at low estimates of R0 (1.45). This requirement increased to 95% at high estimates of R0 (2.47). Extending the treatment interval to 12 months increased requirements at all estimates of R0. At high estimates of R0 with 12 monthly rounds of treatment, no combination of variables achieved eradication. Models should be used to guide the scale-up of yaws eradication.

Subject:

[+]

Pubmed ID:

27983500

Pubmed Central ID:

PMC5176210

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

	16-0487-F1.gif	image/gif
	16-0487-F1.jpg	image/jpeg
	16-0487-F2.gif	image/gif
	16-0487-F2.jpg	image/jpeg
	16-0487-Techapp-s1.pdf	application/pdf
	16-0487.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Francisella tularensis ssp. holarctica in Ringtail Possums, Australia

Personal Author:

Eden, John-Sebastian; Rose, Karrie; Ng, Jimmy; Shi, Mang; Wang, Qinning; Sintchenko, Vitali; Holmes, Edward C.;

Published Date:

Jul 2017

Source:

Emerg Infect Dis. 23(7):1198-1201.

Description:

The occurrence of Francisella tularensis outside of endemic areas, such as North America and Eurasia, has been enigmatic. We report the metagenomic discovery and isolation of F. tularensis ssp. holarctica biovar japonica from diseased ringtail possum...

File Type:

[PDF - 1.31 MB]
US Centers for Disease Control and Prevention and Its Partners’ Contributions to Global Health Security

Personal Author:

Tappero, Jordan W.; Cassell, Cynthia H.; Bunnell, Rebecca E.; Angulo, Frederick J.; Craig, Allen; Pesik, Nicki; Dahl, Benjamin A.; Ijaz, Kashef; Jafari, Hamid; Martin, Rebecca;

Corporate Authors:

Global Health Security Science Group

Published Date:

December 2017

Source:

Emerg Infect Dis. 23(Suppl 1):S5-S14

Description:

To achieve compliance with the revised World Health Organization International Health Regulations (IHR 2005), countries must be able to rapidly prevent, detect, and respond to public health threats. Most nations, however, remain unprepared to manage ...

File Type:

[PDF - 2.73 MB]
Advances in global measles control and elimination; summary of the 1997 International Meeting

Corporate Authors:

Meeting on Advances in Measles Control and Elimination, (3rd : 1997 : Atlanta, Ga.). Centers for Disease Control and Prevention (U.S.). National Immunization Program (Centers for Disease Control and Prevention). Special Program for Vaccines and Immunization. Task Force for Child Survival and Development. World Health Organization, Expanded Programme on Immunization..

Published Date:

July 24, 1998

Series:

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports ; v.47, no. RR-11

Description:

A meeting concerning advances in measles control and elimination, the third in a series, was held in Atlanta during August 1997. The meeting was cosponsored by CDC, the Pan American Health Organization, the World Health Organization, and the United N...

File Type:

[PDF - 351.31 KB]
Global Polio Eradication Initiative; strategic plan, 2010-2012

Corporate Authors:

World Health Organization, Global Polio Eradication Initiative.. Centers for Disease Control and Prevention (U.S.). Rotary International. UNICEF.

Published Date:

2010

Description:

Alarmed that polio remained entrenched in the four countries that had never stopped transmission1, and that an increasing number of polio-free areas were becoming reinfected, in May 2008 the World Health Assembly (WHA) called for a new strategy to co...

File Type:

[PDF - 6.79 MB]
Multiplex Mediator Displacement Loop-Mediated Isothermal Amplification for Detection of Treponema pallidum and Haemophilus ducreyi

Personal Author:

Becherer, Lisa; Knauf, Sascha; Marks, Michael; Lueert, Simone; Frischmann, Sieghard; Borst, Nadine; von Stetten, Felix; Bieb, Sibauk; Adu-Sarkodie, Yaw; Asiedu, Kingsley; Mitjà, Oriol; Bakheit, Mohammed;

Published Date:

Feb 2020

Source:

Emerg Infect Dis. 26(2):282-288

Description:

Yaws, a neglected tropical disease caused by the bacterium Treponema pallidum subspecies pertenue, manifests as ulcerative skin lesions. Nucleic acid amplification tests, like loop-mediated isothermal amplification (LAMP), are versatile tools to dist...

File Type:

[PDF - 1.80 MB]