Mortality Hazard and Survival After Tuberculosis Treatment

Details

• Alternative Title:
  Am J Public Health
• Personal Author:
  Miller, Thaddeus L. ; Wilson, Fernando A. ; Pang, Jenny W. ; Beavers, Suzanne ; Hoger, Sally ; Sharnprapai, Sharon ; Pagaoa, Melissa ; Katz, Dolly J. ; Weis, Stephen E.
• Corporate Authors:
  for the Tuberculosis Epidemiologic Studies Consortium
• Description:
  Objectives
  
  We compared mortality among tuberculosis (TB) survivors and a similar population.
  
  Methods
  
  We used local health authority records from3 US sites to identify 3853 persons who completed adequate treatment of TB and 7282 individuals diagnosed with latent TB infection 1993 to 2002. We then retrospectively observed mortality after 6 to 16 years of observation. We ascertained vital status as of December 31, 2008, using the Centers for Disease Control and Prevention’s National Death Index. We analyzed mortality rates, hazards, and associations using Cox regression.
  
  Results
  
  We traced 11 135 individuals over 119 772 person-years of observation. We found more all-cause deaths (20.7% vs 3.1%) among posttreatment TB patients than among the comparison group, an adjusted average excess of 7.6 deaths per 1000 person-years (8.8 vs 1.2; P < .001). Mortality among posttreatment TB patients varied with observable factors such as race, site of disease, HIV status, and birth country.
  
  Conclusions
  
  Fully treated TB is still associated with substantial mortality risk. Cure as currently understood may be insufficient protection against TB-associated mortality in the years after treatment, and TB prevention may be a valuable opportunity to modify this risk.
  
  
• Keywords:
  Adolescent Adult Aged Cause Of Death Centers For Disease Control And Prevention, U.S. Female HIV Infections Humans Latent Tuberculosis Male Middle Aged Racial Groups Retrospective Studies Risk Factors Survivors Time Factors Tuberculosis United States Young Adult

  More +
• Source:
  Am J Public Health. 105(5):930-937
• Pubmed ID:
  25790407
• Pubmed Central ID:
  PMC4386531
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  105
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:459f0de437f0cd9490293015708880192b3efaa87728250421cb6eeaa03cca60
• Download URL:
  https://stacks.cdc.gov/view/cdc/43400/cdc_43400_DS1.pdf
• File Type:
  [PDF - 733.08 KB ]