Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A(H1N1)pdm09 disease

Kim, Jin Hyang; Reber, Adrian J.; Kumar, Amrita; Ramos, Patricia; Sica, Gabriel; Music, Nedzad; Guo, Zhu; Mishina, Margarita; Stevens, James; York, Ian A.; Jacob, Joshy; Sambhara, Suryaprakash

doi:10.1038/srep37341

i

Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A(H1N1)pdm09 disease

Supporting Files Public Domain

Nov 16 2016
By Kim, Jin Hyang ; Reber, Adrian J. ; Kumar, Amrita ; ...

File Language:

English

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Alternative Title:

Sci Rep
Personal Author:

Kim, Jin Hyang ; Reber, Adrian J. ; Kumar, Amrita ; Ramos, Patricia ; Sica, Gabriel ; Music, Nedzad ; Guo, Zhu ; Mishina, Margarita ; Stevens, James ; York, Ian A. ; Jacob, Joshy ; Sambhara, Suryaprakash
Description:

The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, we investigated if prior immunization with TIV enhanced disease upon A(H1N1)pdm09 infection in mice. We found that A(H1N1)pdm09 infection in TIV-immunized mice did not enhance the disease, as measured by morbidity and mortality. Instead, TIV-immunized mice cleared A(H1N1)pdm09 virus and recovered at an accelerated rate compared to control mice. Prior TIV immunization was associated with potent inflammatory mediators and virus-specific CD8 T cell activation, but efficient immune regulation, partially mediated by IL-10R-signaling, prevented enhanced disease. Furthermore, in contrast to suggested pathological roles, pre-existing non-neutralizing antibodies (NNAbs) were not associated with enhanced virus replication, but rather with promoted antigen presentation through FcR-bearing cells that led to potent activation of virus-specific CD8 T cells. These findings provide new insights into interactions between pre-existing immunity and pandemic viruses.
Subjects:

Animals Antibodies, Viral CD8-Positive T-Lymphocytes Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Vaccines Lymphocyte Activation Mice, Inbred BALB C Orthomyxoviridae Infections Receptors, Interleukin-10 Seasons Signal Transduction Vaccination
Source:

Sci Rep. 2016; 6.
Pubmed ID:

27849030
Pubmed Central ID:

PMC5110975
Document Type:

Journal Article
Volume:

6
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:13ede643f75a094f7577b5adf0fb4f991b6f201dfbcb86bb386ac5bd782a6c30
Download URL:

https://stacks.cdc.gov/view/cdc/43287/cdc_43287_DS1.pdf
File Type:

[PDF - 1.76 MB ]

File Language:

English

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