The utility of stool cultures for diagnosing tuberculosis in people living with the human immunodeficiency virus

Details

• Alternative Title:
  Int J Tuberc Lung Dis
• Personal Author:
  Oramasionwu, G. E. ; Heilig, C. M. ; Udomsantisuk, N. ; Kimerling, M. E. ; Eng, B. ; Nguyen, H. D. ; Thai, S. ; Keo, C. ; McCarthy, K. D. ; Varma, J. K. ; Cain, K. P.
• Description:
  BACKGROUND
  
  Delayed diagnosis of tuberculosis (TB) increases mortality.
  
  OBJECTIVE
  
  To evaluate whether stool culture improves the diagnosis of TB in people living with the human immunodeficiency virus (PLHIV).
  
  DESIGN
  
  We analysed cross-sectional data of TB diagnosis in PLHIV in Cambodia, Thailand and Viet Nam. Logistic regression was used to assess the association between positive stool culture and TB, and to calculate the incremental yield of stool culture.
  
  RESULTS
  
  A total of 1693 PLHIV were enrolled with a stool culture result. Of 228 PLHIV with culture-confirmed TB from any site, 101 (44%) had a positive stool culture; of these, 91 (90%) had pulmonary TB (PTB). After adjusting for confounding factors, a positive stool culture was associated with smear-negative (odds ratio [OR] 26, 95% confidence interval [CI] 12–58), moderately smear-positive (OR 60, 95%CI 23–159) and highly smear-positive (OR 179, 95%CI 59–546) PTB compared with no PTB. No statistically significant association existed with extrapulmonary TB compared with no extrapulmonary TB (OR 2, 95%CI 1–5). The incremental yield of one stool culture above two sputum cultures (5%, 95%CI 3–8) was comparable to an additional sputum culture (7%, 95%CI 4–11).
  
  CONCLUSION
  
  Nearly half of the PLHIV with TB had a positive stool culture that was strongly associated with PTB. Stool cultures may be used to diagnose TB in PLHIV.
  
  
• Subjects:
  Adult Cross-Sectional Studies Delayed Diagnosis Feces Female HIV Infections Humans Logistic Models Male Sputum Tuberculosis Tuberculosis, Pulmonary

  More +
• Source:
  Int J Tuberc Lung Dis. 17(8):1023-1028
• Pubmed ID:
  23827025
• Pubmed Central ID:
  PMC5152914
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Thailand ; Vietnam
• Volume:
  17
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3e413cfd11f9dc7fb85e2c586dd8460026fa8c9dc5242793600c95cf7f13ec5c
• Download URL:
  https://stacks.cdc.gov/view/cdc/43213/cdc_43213_DS1.pdf
• File Type:
  [PDF - 553.42 KB ]