Urinary Polycyclic Aromatic Hydrocarbon (OH-PAH) Metabolite Concentrations and the Effect of GST Polymorphisms Among US Air Force Personnel Exposed to Jet Fuel

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Rodrigues, Ema G. ; Smith, Kristen ; Maule, Alexis L. ; Sjodin, Andreas ; Li, Zheng ; Romanoff, Lovisa ; Kelsey, Karl ; Proctor, Susan ; McClean, Michael D.
• Description:
  Objective
  
  To evaluate the association between inhalation exposure to jet propulsion fuel 8 (JP-8) and urinary metabolites among US Air Force (USAF) personnel, and investigate the role of glutathione S-transferase polymorphisms.
  
  Methods
  
  Personal air samples were collected from 37 full-time USAF personnel during 4 consecutive workdays and analyzed for JP-8 constituents and total hydrocarbons. Pre- and postshift urine samples were collected each day and analyzed for polycyclic aromatic hydrocarbon urinary metabolites.
  
  Results
  
  Work shift exposure to total hydrocarbons was significantly associated with postshift urinary 1-naphthol (β = 0.17; P = <0.0001), 2-naphthol (β = 0.09; P = 0.005), and 2-hydroxyfluorene concentrations (β = 0.08; P = 0.006), and a significant gene-environment interaction was observed with glutathione S-transferase mu-1.
  
  Conclusions
  
  USAF personnel experience inhalation exposure to JP-8, which is associated with absorption of JP-8 constituents while performing typical job-related tasks, and in our data the glutathione S-transferase mu-1 polymorphism was associated with differential metabolism of naphthalene.
  
  
• Subjects:
  Adolescent Adult Air Pollutants, Occupational Female Glutathione Transferase Humans Hydrocarbons Inhalation Exposure Male Military Personnel Polycyclic Aromatic Hydrocarbons Polymorphism, Genetic Young Adult

  More +
• Source:
  J Occup Environ Med. 56(5):465-471.
• Pubmed ID:
  24806557
• Pubmed Central ID:
  PMC5137189
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  56
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8fc9efe08905a28d703fe5894a7e0c1a2ac795ce1d8170eb0ed3ee63ecefccbe
• Download URL:
  https://stacks.cdc.gov/view/cdc/43118/cdc_43118_DS1.pdf
• File Type:
  [PDF - 555.37 KB ]