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Bordetella pertussis variants lacking the vaccine antigen pertactin: first detection in the United States
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  1. Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin
    Personal Author:
    Williams, Margaret M.; Sen, Kathryn; Weigand, Michael R.; Skoff, Tami H.; Cunningham, Victoria A.; Halse, Tanya A.; Tondella, M. Lucia;
    Corporate Author:
    CDC Pertussis Working Group
    Published:
    Feb 2016
    Source:
    Emerg Infect Dis. 22(2):319-322.
    Description:
    A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013. Comparison with a French strain that was pertussis toxin-deficient, pertactin wil...
    File Type:
    Filetype[PDF - 371.16 KB]
  2. Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia
    Personal Author:
    Lam, Connie; Octavia, Sophie; Ricafort, Lawrence; Sintchenko, Vitali; Gilbert, Gwendolyn L.; Wood, Nicholas; McIntyre, Peter; Marshall, Helen; Guiso, Nicole; Keil, Anthony D.; Lawrence, Andrew; Robson, Jenny; Hogg, Geoff; Lan, Ruiting;
    Published:
    Apr 2014
    Source:
    Emerg Infect Dis. 20(4):626-633.
    Description:
    Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis...
    File Type:
    Filetype[PDF - 565.65 KB]
  3. Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan
    Personal Author:
    Hiramatsu, Yukihiro; Miyaji, Yusuke; Otsuka, Nao; Arakawa, Yoshichika; Shibayama, Keigo; Kamachi, Kazunari;
    Published:
    Apr 2017
    Source:
    Emerg Infect Dis. 23(4):699-701.
    Description:
    Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014-2016 (8%) was significantly lower than the frequency in 2005-2007 (41%),...
    File Type:
    Filetype[PDF - 447.03 KB]
  4. Changes in Predominance and Diversity of Genomic Subtypes of Bordetella pertussis Isolated in the United States, 1935 to 1999
    Personal Author:
    Hardwick, Terri Hawes; Cassiday, Pamela; Weyant, Robbin S.; Bisgard, Kristine M.; Sanden, Gary N.;
    Published:
    Jan 2002
    Source:
    Emerg Infect Dis. 8(1):44-49.
    Description:
    Pulsed-field gel electrophoresis (PFGE) of Bordetella pertussis chromosomal DNA fragments generated by XbaI restriction has been used to subtype isolates for epidemiologic studies. To better understand the natural history of pertussis, we determined ...
    File Type:
    Filetype[PDF - 274.92 KB]
  5. Rapid identification of Bordetella pertussis pertactin gene variants using LightCycler real-time polymerase chain reaction combined with melting curve analysis and gel electrophoresis.
    Personal Author:
    Mäkinen, J.; Viljanen, M. K.; Mertsola, J.; Arvilommi, H.; He, Q.;
    Published:
    2001 Nov-Dec
    Source:
    Emerg Infect Dis. 7(6):952-958.
    Description:
    Recently, eight allelic variants of the pertactin gene (prn1-8) have been characterized in Bordetella pertussis strains isolated in Europe and the United States. It has been suggested that the divergence of the pertactin types of clinical isolates fr...
    File Type:
    Filetype[PDF - 110.88 KB]