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Comparison of cancer diagnoses between the US solid organ transplant registry and linked central cancer registries
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Details:
  • Pubmed ID:
    27062091
  • Pubmed Central ID:
    PMC5055411
  • Description:
    US transplant centers are required to report cancers in transplant recipients to the transplant network. The accuracy and completeness of these data, collected in the Scientific Registry of Transplant Recipients (SRTR), are unknown. We compared diagnoses in the SRTR and 15 linked cancer registries for colorectal, liver, lung, breast, prostate and kidney cancers; melanoma; and non-Hodgkin lymphoma (NHL). Among 187 384 transplants, 9323 cancers were documented in the SRTR or cancer registries. Only 36.8% of cancers were in both, with 47.5% and 15.7% of cases additionally documented solely in cancer registries or the SRTR, respectively. Agreement between the SRTR and cancer registries varied (kappa = 0.28 for liver cancer and kappa = 0.52-0.66 for lung, prostate, kidney, colorectum, and breast cancers). Upon evaluation, some NHLs documented only in cancer registries were identified in the SRTR as another type of posttransplant lymphoproliferative disorder. Some SRTR-only cases were explained by miscoding (colorectal cancer instead of anal cancer, metastases as lung or liver cancers) or missed matches with cancer registries, partly due to recipients' outmigration from catchment areas. Estimated sensitivity for identifying cancer was 52.5% for the SRTR and 84.3% for cancer registries. In conclusion, SRTR cancer data are substantially incomplete, limiting their usefulness for surveillance and research.

  • Document Type:
  • Collection(s):
  • Funding:
    U58 DP003931/DP/NCCDPHP CDC HHS/United States
    HHSN261201000037C/CA/NCI NIH HHS/United States
    N01PC35143/CA/NCI NIH HHS/United States
    HHSN261201000035C/PC,CA/None/None
    U58 DP003883/DP/NCCDPHP CDC HHS/United States
    U58 DP003875/DP/NCCDPHP CDC HHS/United States
    P30 CA086862/CA/NCI NIH HHS/United States
    HHSN261201000036C/CA/NCI NIH HHS/United States
    U58 DP003879/DP/NCCDPHP CDC HHS/United States
    N01PC35137/CA/NCI NIH HHS/United States
    HHSN261201300071C/CA/NCI NIH HHS/United States
    U58 DP003920/DP/NCCDPHP CDC HHS/United States
    HHSN261201300011C/RC/CCR NIH HHS/United States
    U58 DP000807/DP/NCCDPHP CDC HHS/United States
    N01PC35142/CA/NCI NIH HHS/United States
    HHSN261201300021C/CA/NCI NIH HHS/United States
    HHSN261201000035I/CA/NCI NIH HHS/United States
    U58 DP000848/DP/NCCDPHP CDC HHS/United States
    HHSN261201000024C/CA/NCI NIH HHS/United States
    HHSN261201000034C/CA/NCI NIH HHS/United States
    U58 DP003921/DP/NCCDPHP CDC HHS/United States
    HHSN261201300011I/CA/NCI NIH HHS/United States
    Z01 CP010150-09/Intramural NIH HHS/United States
    U58 DP000832/DP/NCCDPHP CDC HHS/United States
    N01PC35139/CA/NCI NIH HHS/United States
    U58 DP000824/DP/NCCDPHP CDC HHS/United States
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