Details:

Alternative Title:
Accid Anal Prev
Publisher's site:
http://dx.doi.org/10.1016/j.aap.2016.08.001
Personal Author:
Rudisill, Toni M. ; Zhu, Motao ; Kelley, George A. ; Pilkerton, Courtney ; Rudisill, Brandon R.
Rudisill, Toni M. ; Zhu, Motao ; Kelley, George A. ; Pilkerton, Courtney ; Rudisill, Brandon R. Less -
Description:
Objectives

Driving under the influence of prescription and over-the-counter medication is a growing public health concern. A systematic review of the literature was performed to investigate which specific medications were associated with increased risk of motor vehicle collision (MVC).

Methods

The a priori inclusion criteria were: 1) studies published from English-language sources on or after January 1, 1960, 2) licensed drivers 15 years of age and older, 3) peer-reviewed publications, master's theses, doctoral dissertations, and conference papers, 4) studies limited to randomized control trials, cohort studies, case-control studies, or case-control type studies 5) outcome measure reported for at least one specific medication, 6) outcome measure reported as the odds or risk of a motor vehicle collision. Fourteen databases were examined along with hand-searching. Independent, dual selection of studies and data abstraction was performed.

Results

Fifty-three medications were investigated by 27 studies included in the review. Fifteen (28.3%) were associated with an increased risk of MVC. These included Buprenorphine, Codeine, Dihydrocodeine, Methadone, Tramadol, Levocitirizine, Diazepam, Flunitrazepam, Flurazepam, Lorazepam, Temazepam, Triazolam, Carisoprodol, Zolpidem, and Zopiclone.

Conclusions

Several medications were associated with an increased risk of MVC and decreased driving ability. The associations between specific medication use and the increased risk of MVC and/or affected driving ability are complex. Future research opportunities are plentiful and worthy of such investigation.


Subject:
[+]
Ability
Accidents, Traffic
Adult
Analgesics, Opioid
Antidepressive Agents
Article
Automobile Driving
Cohort Studies
Dose-Response Relationship, Drug
Driving
Driving Under The Influence
Drugs
Humans
Male
Middle Aged
Motor Vehicles
Prescription
Review
Risk Factors
Young Adult

Source:
Accid Anal Prev. 96:255-270.
Pubmed ID:
27569655
Pubmed Central ID:
PMC5045819
Document Type:
Journal Article
Funding:
R21 HD085122/HD/NICHD NIH HHS/United States ; R01 AG050581/AG/NIA NIH HHS/United States ; R21 CE001820/CE/NCIPC CDC HHS/United States ; U54 GM104942/GM/NIGMS NIH HHS/United States ; R01 HD074594/HD/NICHD NIH HHS/United States
R21 HD085122/HD/NICHD NIH HHS/United States ; R01 AG050581/AG/NIA NIH HHS/United States ; R21 CE001820/CE/NCIPC CDC HHS/United States ; U54 GM104942/GM/NIGMS NIH HHS/United States ; R01 HD074594/HD/NICHD NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1846ac8b1e980e16d7761bc232eef562698457535e24b903c4f7af93274c9a7e
File Type:

Supporting Files

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