Increased Hospitalizations for Neuropathies as Indicators of Zika Virus Infection, according to Health Information System Data, Brazil

Barcellos, Christovam; Xavier, Diego Ricardo; Pavão, Ana Luiza; Boccolini, Cristiano Siqueira; Pina, Maria Fatima; Pedroso, Marcel; Romero, Dalia; Romão, Anselmo Rocha

doi:10.3201/eid2211.160901

i

Increased Hospitalizations for Neuropathies as Indicators of Zika Virus Infection, according to Health Information System Data, Brazil

Supporting Files Public Domain

Nov 15 2016
By Barcellos, Christovam ; Xavier, Diego Ricardo ; Pavão, Ana Luiza ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Barcellos, Christovam ; Xavier, Diego Ricardo ; Pavão, Ana Luiza ; Boccolini, Cristiano Siqueira ; Pina, Maria Fatima ; Pedroso, Marcel ; Romero, Dalia ; Romão, Anselmo Rocha
Description:

Evidence is increasing that Zika virus can cause extensive damage to the central nervous system, affecting both fetuses and adults. We sought to identify traces of possible clinical manifestations of nervous system diseases among the registers of hospital admissions recorded in the Brazilian Unified Health System. Time series of several diagnoses from the International Classification of Diseases, 10th Revision, were analyzed by using control diagrams, during January 2008-February 2016. Beginning in mid-2014, we observed an unprecedented and significant rise in the hospitalization rate for congenital malformations of the nervous system, Guillain-Barré syndrome, encephalitis, myelitis, and encephalomyelitis. These conditions are compatible with viral infection and inflammation-associated manifestations and may have been due to the entrance of Zika virus into Brazil. These findings show the necessity of adequately diagnosing and treating suspected cases of Zika virus infection and also that health surveillance systems can be improved by using routine data.
Subjects:

Disease Outbreaks Geography, Medical Health Status Indicators Hospitalization Humans Nervous System Diseases Nervous System Malformations Population Surveillance Zika Virus Zika Virus Infection
Source:

Emerg Infect Dis. 22(11):1894-1899.
Pubmed ID:

27603576
Pubmed Central ID:

PMC5088029
Document Type:

Journal Article
Place as Subject:

Brazil
Volume:

22
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:e789907bf742c3577c47d342fae7d91ac77fe21d1720df5053aa8921e641421d
Download URL:

https://stacks.cdc.gov/view/cdc/42824/cdc_42824_DS1.pdf
File Type:

[PDF - 980.65 KB ]

File Language:

English

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