Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Zhu, Wenfei ; Zhang, Hong ; Xiang, Xingyu ; Zhong, Lili ; Yang, Lei ; Guo, Junfeng ; Xie, Yiran ; Li, Fangcai ; Deng, Zhihong ; Feng, Hong ; Huang, Yiwei ; Hu, Shixiong ; Xu, Xin ; Zou, Xiaohui ; Li, Xiaodan ; Bai, Tian ; Chen, Yongkun ; Li, Zi ; Li, Junhua ; Shu, Yuelong
• Description:
  In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans.
• Subjects:
  Animals Cell Line Genes, Viral History, 21St Century Humans Infant Influenza, Human/Diagnosis Influenza, Human/Epidemiology Influenza, Human/History Influenza, Human/Virology Influenza A Virus, H1N1 Subtype/Classification Influenza A Virus, H1N1 Subtype/Genetics Influenza A Virus, H1N1 Subtype/Isolation & Purification Influenza A Virus, H1N1 Subtype/Pathogenicity Multilocus Sequence Typing Phylogeny Reassortant Viruses Rna, Viral Serologic Tests Severity Of Illness Index Virulence Virus Replication

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• Source:
  Emerg Infect Dis. 22(11):1930-1936.
• Pubmed ID:
  27767007
• Pubmed Central ID:
  PMC5088044
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  22
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:232ffae7117ffbb2bdc8603017ebcd910b4e1e8a46790135690f5b28ccbaab7f
• Download URL:
  https://stacks.cdc.gov/view/cdc/42804/cdc_42804_DS1.pdf
• File Type:
  [PDF - 2.38 MB ]