Transmission of Babesia microti Parasites by Solid Organ Transplantation

Brennan, Meghan B.; Herwaldt, Barbara L.; Kazmierczak, James J.; Weiss, John W.; Klein, Christina L.; Leith, Catherine P.; He, Rong; Oberley, Matthew J.; Tonnetti, Laura; Wilkins, Patricia P.; Gauthier, Gregory M.

doi:10.3201/eid2211.151028

i

Transmission of Babesia microti Parasites by Solid Organ Transplantation

Supporting Files

Nov 2016
By Brennan, Meghan B. ; Herwaldt, Barbara L. ; Kazmierczak, James J. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Brennan, Meghan B. ; Herwaldt, Barbara L. ; Kazmierczak, James J. ; Weiss, John W. ; Klein, Christina L. ; Leith, Catherine P. ; He, Rong ; Oberley, Matthew J. ; Tonnetti, Laura ; Wilkins, Patricia P. ; Gauthier, Gregory M.
Description:

Babesia microti, an intraerythrocytic parasite, is tickborne in nature. In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttransplantation in 2 recipients of renal allografts from an organ donor who was multiply transfused on the day he died from traumatic injuries. The organ donor and recipients had no identified risk factors for tickborne infection. Antibodies against B. microti parasites were not detected by serologic testing of archived pretransplant specimens. However, 1 of the organ donor's blood donors was seropositive when tested postdonation and had risk factors for tick exposure. The organ donor probably served as a conduit of Babesia parasites from the seropositive blood donor to both kidney recipients. Babesiosis should be included in the differential diagnosis of unexplained fever and hemolytic anemia after blood transfusion or organ transplantation.
Subjects:

Adult Aged Babesia Microti Babesiosis Biomarkers Blood Transfusion Erythrocytes/parasitology Erythrocytes/pathology Humans Kidney Transplantation/adverse Effects Male Organ Transplantation/adverse Effects Synopsis Time Factors Tissue Donors Tomography, X-Ray Computed Transplantation, Homologous
Source:

Emerg Infect Dis. 22(11):1869-1876.
Pubmed ID:

27767010
Pubmed Central ID:

PMC5088010
Document Type:

Journal Article
Funding:

KL2 TR000428/TR/NCATS NIH HHS/United States ; UL1 TR000427/TR/NCATS NIH HHS/United States
Volume:

22
Issue:

11
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:50b65e415a28f0a0a705696dbb7cd67d8e3e81e410bba41dde066e0d568e6056
Download URL:

https://stacks.cdc.gov/view/cdc/42798/cdc_42798_DS1.pdf
File Type:

[PDF - 1.12 MB ]

File Language:

English

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