Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men

Leeyaphan, Charussri; Ong, Jason J.; Chow, Eric P.F.; Kong, Fabian Y.S.; Hocking, Jane S.; Bissessor, Melanie; Fairley, Christopher K.; Chen, Marcus

doi:10.3201/eid2210.160986

i

Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men

Supporting Files Public Domain

Oct 15 2016
By Leeyaphan, Charussri ; Ong, Jason J. ; Chow, Eric P.F. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Leeyaphan, Charussri ; Ong, Jason J. ; Chow, Eric P.F. ; Kong, Fabian Y.S. ; Hocking, Jane S. ; Bissessor, Melanie ; Fairley, Christopher K. ; Chen, Marcus
Description:

Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%-100%, I (2) = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.
Subjects:

Bacteria Chlamydia Chlamydia Trachomatis Doxycycline Efficacy Men Who Have Sex With Men Meta-analysis Rectal Lymphogranuloma Venereum Research Sexually Transmitted Infection STI Systematic Review Treatment
Source:

Emerg Infect Dis. 22(10):1778-1784.
Pubmed ID:

27513890
Pubmed Central ID:

PMC5038401
Document Type:

Journal Article
Volume:

22
Issue:

10
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2a8e6ec0de54f3943e6778e6ae6846a23c04986fccac34d76fe31b4ffcf8fe8a
Download URL:

https://stacks.cdc.gov/view/cdc/42772/cdc_42772_DS1.pdf
File Type:

[PDF - 610.54 KB ]

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