In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses

Details

• Alternative Title:
  Antiviral Res
• Personal Author:
  Lo, Michael K. ; Shi, Pei-Yong ; Chen, Yen-Liang ; Flint, Mike ; Spiropoulou, Christina F.
• Description:
  There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity.
• Subjects:
  Adenosine Antiviral Agents Cell Line Cells, Cultured Cytopathogenic Effect, Viral Dose-Response Relationship, Drug Flavivirus Flavivirus Infections Humans Tick-Borne Diseases Virus Replication

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• Source:
  Antiviral Res. 130:46-49.
• Pubmed ID:
  27016316
• Pubmed Central ID:
  PMC5096641
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  130
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e70c4c726ca30d757596f16b1e3e5929d27070909fa692f1c70e6f84f6177346
• Download URL:
  https://stacks.cdc.gov/view/cdc/42715/cdc_42715_DS1.pdf
• File Type:
  [PDF - 525.80 KB ]