Antifungal azoles itraconazole and posaconazole exhibit potent in vitro antiviral activity against clinical isolates of parechovirus A3 (Picornaviridae)☆☆

Details

• Alternative Title:
  Antiviral Res
• Personal Author:
  Rhoden, Eric ; Nix, W. Allan ; Weldon, William C. ; Selvarangan, Rangaraj
• Description:
  Parechovirus A3 (Par-A3, formerly human parechovirus 3) is an emerging viral infection of the central nervous system in children. We used an automated, homogeneous, cell based assay to identify itraconazole and posaconazole as inhibitors of Par-A3, with antiviral activity below concentrations clinically attainable in pediatric patients. Currently, there is no approved antiviral treatment for Par-A3 infection, despite numerous reports of serious Par-A3 disease in neonates and infants.
• Subjects:
  Animals Antifungal Agents Antiviral Agents Article Cell Line Cells, Cultured Cytopathogenic Effect, Viral Dose-Response Relationship, Drug Humans Itraconazole Parechovirus Picornaviridae Infections Triazoles

  More +
• Source:
  Antiviral Res. 149:75-77
• Pubmed ID:
  29155163
• Pubmed Central ID:
  PMC9169550
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  149
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e5268233f6341e927b46bee05b991f36cf6160feb67cdc0e3e1d0fa27873d5e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/119233/cdc_119233_DS1.pdf
• File Type:
  [PDF - 312.29 KB ]