Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Bowen, Michael D. ; Mijatovic-Rustempasic, Slavica ; Esona, Mathew D. ; Teel, Elizabeth N. ; Gautam, Rashi ; Sturgeon, Michele ; Azimi, Parvin H. ; Baker, Carol J. ; Bernstein, David I. ; Boom, Julie A. ; Chappell, James ; Donauer, Stephanie ; Edwards, Kathryn M. ; Englund, Janet A. ; Halasa, Natasha B. ; Harrison, Christopher J. ; Johnston, Samantha H. ; Klein, Eileen J. ; McNeal, Monica M. ; Moffatt, Mary E. ; Rench, Marcia A. ; Sahni, Leila C. ; Selvarangan, Rangaraj ; Staat, Mary A. ; Szilagyi, Peter G. ; Weinberg, Geoffrey A. ; Wikswo, Mary E. ; Parashar, Umesh D. ; Payne, Daniel C.
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• Description:
  Background ; Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3–7 geographically diverse sites in the United States since 2006. ; Methods ; Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping. ; Results ; In the 2009, 2010, and 2011 seasons, genotype G3P8 was the predominant genotype throughout the network, with a 46%–84% prevalence. In the 2012 season, G12P8 replaced G3P8 as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%–3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P4, G3P24, G2P8, G3P4, G3P6, G24P14, G4P6, and G9P4) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype. ; Conclusions ; Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.
• Keywords:
  • rotavirus
  • genotype
  • prevalence
  • surveillance
  • vaccine
  • Child
  • Child, Preschool
  • Epidemiological Monitoring
  • Female
  • Genotype
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• Source:
  J Infect Dis. 214(5):732-738
• Pubmed ID:
  27302190
• Pubmed Central ID:
  PMC5075963
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; U01 IP000461/IP/NCIRD CDC HHSUnited States/ ; U01 IP001049/IP/NCIRD CDC HHSUnited States/ ; U01 IP001050/IP/NCIRD CDC HHSUnited States/
• Volume:
  214
• Issue:
  5
• Download URL:
  https://stacks.cdc.gov/view/cdc/42221/cdc_42221_DS1.pdf
• File Type:
  [PDF - 205.88 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1ab0c9c47af4db949d506f95b146dbd9eb702361ddcdfdaba8e7fa76902aa47a