Trends in Primary Central Nervous System Lymphoma Incidence and Survival in the U.S

Details

• Alternative Title:
  Br J Haematol
• Personal Author:
  Shiels, Meredith S. ; Pfeiffer, Ruth M. ; Besson, Caroline ; Clarke, Christina A. ; Morton, Lindsay M. ; Nogueira, Leticia ; Pawlish, Karen ; Yanik, Elizabeth L. ; Suneja, Gita ; Engels, Eric A.
• Description:
  It is suspected that primary central nervous system lymphoma (PCNSL) rates are increasing among immunocompetent people. We estimated PCNSL trends in incidence and survival among immunocompetent persons by excluding cases among human immunodeficiency virus (HIV)-infected persons and transplant recipients. PCNSL data were derived from 10 Surveillance, Epidemiology and End Results (SEER) cancer registries (1992-2011). HIV-infected cases had reported HIV infection or death due to HIV. Transplant recipient cases were estimated from the Transplant Cancer Match Study. We estimated PCNSL trends overall and among immunocompetent individuals, and survival by HIV status. A total of 4158 PCNSLs were diagnosed (36% HIV-infected; 0·9% transplant recipients). HIV prevalence in PCNSL cases declined from 64·1% (1992-1996) to 12·7% (2007-2011), while the prevalence of transplant recipients remained low. General population PCNSL rates were strongly influenced by immunosuppressed cases, particularly in 20-39 year-old men. Among immunocompetent people, PCNSL rates in men and women aged 65+ years increased significantly (1·7% and 1·6%/year), but remained stable in other age groups. Five-year survival was poor, particularly among HIV-infected cases (9·0%). Among HIV-uninfected cases, 5-year survival increased from 19·1% (1992-1994) to 30·1% (2004-2006). In summary, PCNSL rates have increased among immunocompetent elderly adults, but not in younger individuals. Survival remains poor for both HIV-infected and HIV-uninfected PCNSL patients.
• Subjects:
  Adult Aged Age Factors Central Nervous System Neoplasms Female HIV Infections Humans Immunocompetence Incidence Lymphoma Male Middle Aged Registries Sex Factors Survival Analysis Transplant Recipients United States Young Adult

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• Keywords:
  Central Nervous System HIV Incidence Lymphoma Survival Transplant
• Source:
  Br J Haematol. 174(3):417-424
• Pubmed ID:
  27018254
• Pubmed Central ID:
  PMC4961566
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000037C/CA/NCI NIH HHSUnited States/ ; N01PC35143/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35137/CA/NCI NIH HHSUnited States/ ; HHSN261201300071C/CA/NCI NIH HHSUnited States/ ; U58 DP003920/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000807/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000848/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP003883/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; HHSN261201000036C/CA/NCI NIH HHSUnited States/ ; U58 DP003879/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35142/CA/NCI NIH HHSUnited States/ ; Z99 CA999999/ImNIH/Intramural NIH HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; HHSN261201000024C/CA/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003921/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP000832/DP/NCCDPHP CDC HHSUnited States/ ; N01PC35139/CA/NCI NIH HHSUnited States/ ; HHSN261201300011C/CA/NCI NIH HHSUnited States/ ; U58 DP000824/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  174
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:70acd549cbd7d4f10abb82cc2f610ab7901a26e2c3ff2a2e642853942e64fed6
• Download URL:
  https://stacks.cdc.gov/view/cdc/42139/cdc_42139_DS1.pdf
• File Type:
  [PDF - 527.08 KB ]