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Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia
  • Published Date:
    2016
  • Source:
    Curr HIV Res. 14(4):324-330.
Filetype[PDF - 455.14 KB]


Details:
  • Pubmed ID:
    26673902
  • Pubmed Central ID:
    PMC4916008
  • Description:
    Background

    Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIV-infected patients.

    Objective

    To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).

    Methods

    One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.

    Results

    FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).

    Conclusions

    FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.

  • Document Type:
  • Collection(s):
  • Funding:
    K99 AG048762/AG/NIA NIH HHS/United States
    U01 AI035042/AI/NIAID NIH HHS/United States
    R01 AG042165/AG/NIA NIH HHS/United States
    R01 NS079166/NS/NINDS NIH HHS/United States
    R03 DA022137/DA/NIDA NIH HHS/United States
    R01 AG034852/AG/NIA NIH HHS/United States
    P50 DA026306/DA/NIDA NIH HHS/United States
    R01 MH078748/MH/NIMH NIH HHS/United States
    HHSN271201000030C/MH/NIMH NIH HHS/United States
    P30 MH075673/MH/NIMH NIH HHS/United States
    R01 MH092225/MH/NIMH NIH HHS/United States
    U2G PS000623/PS/NCHHSTP CDC HHS/United States
    U24 MH100928/MH/NIMH NIH HHS/United States
    UM1 AI069495/AI/NIAID NIH HHS/United States
    R25 MH081482/MH/NIMH NIH HHS/United States
    R01 MH058076/MH/NIMH NIH HHS/United States
    HHSN271201000036C/MH/NIMH NIH HHS/United States
    R01 MH078737/MH/NIMH NIH HHS/United States
    P01 DA026146/DA/NIDA NIH HHS/United States
    R01 NR012907/NR/NINR NIH HHS/United States
    R01 MH096648/MH/NIMH NIH HHS/United States
    U01 AI069432/AI/NIAID NIH HHS/United States
    R01 DA034497/DA/NIDA NIH HHS/United States
    L30 AG045921/AG/NIA NIH HHS/United States
    R01 MH101017/MH/NIMH NIH HHS/United States
    U13 MH081676/MH/NIMH NIH HHS/United States
    U01 AI069495/AI/NIAID NIH HHS/United States
    P30 MH062512/MH/NIMH NIH HHS/United States
    U01 MH083506/MH/NIMH NIH HHS/United States
    N01 MH022005/MH/NIMH NIH HHS/United States
    K30 RR022681/RR/NCRR NIH HHS/United States
    R01 MH083552/MH/NIMH NIH HHS/United States
    R01 MH099987/MH/NIMH NIH HHS/United States
    R01 NS081196/NS/NINDS NIH HHS/United States
    U24 MH100930/MH/NIMH NIH HHS/United States
    U10 NS077384/NS/NINDS NIH HHS/United States
    R03 AG044910/AG/NIA NIH HHS/United States
    R01 MH060720/MH/NIMH NIH HHS/United States
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