with a Family History of Dementia

Details

• Alternative Title:
  Curr HIV Res
• Personal Author:
  Fazeli, Pariya. L. ; Moore, David J. ; Franklin, Donald R. ; Umlauf, Anya ; Heaton, Robert K. ; Collier, Ann C. ; Marra, Christina M. ; Clifford, David B. ; Gelman, Benjamin B. ; Sacktor, Ned C. ; Morgello, Susan ; Simpson, David M. ; McCutchan, John A. ; Grant, Igor ; Letendre, Scott L.
• Description:
  Background
  
  Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIV-infected patients.
  
  Objective
  
  To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).
  
  Methods
  
  One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.
  
  Results
  
  FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).
  
  Conclusions
  
  FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.
  
  
• Subjects:
  Adult AIDS Dementia Complex Amyloid Beta-Peptides Article Biomarkers Cerebrospinal Fluid Cross-Sectional Studies Dementia Family History Female HIV HIV Infections Humans Male Middle Aged Neurocognitive Impairment

  More +
• Source:
  Curr HIV Res. 14(4):324-330
• Pubmed ID:
  26673902
• Pubmed Central ID:
  PMC4916008
• Document Type:
  Journal Article
• Funding:
  U24 MH100928/MH/NIMH NIH HHSUnited States/ ; R01 NR012907/NR/NINR NIH HHSUnited States/ ; R01 DA034497/DA/NIDA NIH HHSUnited States/ ; P30 MH062512/MH/NIMH NIH HHSUnited States/ ; U01 MH083506/MH/NIMH NIH HHSUnited States/ ; U10 NS077384/NS/NINDS NIH HHSUnited States/ ; R01 MH060720/MH/NIMH NIH HHSUnited States/ ; K99 AG048762/AG/NIA NIH HHSUnited States/ ; U01 AI035042/AI/NIAID NIH HHSUnited States/ ; R01 AG042165/AG/NIA NIH HHSUnited States/ ; R01 NS079166/NS/NINDS NIH HHSUnited States/ ; R03 DA022137/DA/NIDA NIH HHSUnited States/ ; R01 MH080150/MH/NIMH NIH HHSUnited States/ ; R01 AG034852/AG/NIA NIH HHSUnited States/ ; K24 MH097673/MH/NIMH NIH HHSUnited States/ ; P50 DA026306/DA/NIDA NIH HHSUnited States/ ; R01 MH078748/MH/NIMH NIH HHSUnited States/ ; HHSN271201000030C/MH/NIMH NIH HHSUnited States/ ; P30 MH075673/MH/NIMH NIH HHSUnited States/ ; R01 MH092225/MH/NIMH NIH HHSUnited States/ ; U2G PS000623/PS/NCHHSTP CDC HHSUnited States/ ; UM1 AI069495/AI/NIAID NIH HHSUnited States/ ; R25 MH081482/MH/NIMH NIH HHSUnited States/ ; R21 MH100968/MH/NIMH NIH HHSUnited States/ ; R01 MH058076/MH/NIMH NIH HHSUnited States/ ; HHSN271201000036C/MH/NIMH NIH HHSUnited States/ ; R01 MH078737/MH/NIMH NIH HHSUnited States/ ; R01 NS072005/NS/NINDS NIH HHSUnited States/ ; P01 DA026146/DA/NIDA NIH HHSUnited States/ ; UM1 AI035043/AI/NIAID NIH HHSUnited States/ ; R01 MH096648/MH/NIMH NIH HHSUnited States/ ; U01 AI069432/AI/NIAID NIH HHSUnited States/ ; L30 AG045921/AG/NIA NIH HHSUnited States/ ; R01 MH101017/MH/NIMH NIH HHSUnited States/ ; N01MH22005/MH/NIMH NIH HHSUnited States/ ; U13 MH081676/MH/NIMH NIH HHSUnited States/ ; U01 AI069495/AI/NIAID NIH HHSUnited States/ ; N01 MH022005/MH/NIMH NIH HHSUnited States/ ; K30 RR022681/RR/NCRR NIH HHSUnited States/ ; R01 MH083552/MH/NIMH NIH HHSUnited States/ ; R01 MH099987/MH/NIMH NIH HHSUnited States/ ; R01 MH107345/MH/NIMH NIH HHSUnited States/ ; R01 NS081196/NS/NINDS NIH HHSUnited States/ ; U24 MH100930/MH/NIMH NIH HHSUnited States/ ; R03 AG044910/AG/NIA NIH HHSUnited States/ ; R01 MH099733/MH/NIMH NIH HHSUnited States/
• Volume:
  14
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9336f20d0ecc924289f01a441c8fbb91625a0b069d72a6badcce4e3f0d5a221b
• Download URL:
  https://stacks.cdc.gov/view/cdc/42126/cdc_42126_DS1.pdf
• File Type:
  [PDF - 455.14 KB ]