Details:

Alternative Title:
Curr HIV Res
Personal Author:
Fazeli, Pariya. L. ; Moore, David J. ; Franklin, Donald R. ; Umlauf, Anya ; Heaton, Robert K. ; ... More +
Fazeli, Pariya. L. ; Moore, David J. ; Franklin, Donald R. ; Umlauf, Anya ; Heaton, Robert K. ; Collier, Ann C. ; Marra, Christina M. ; Clifford, David B. ; Gelman, Benjamin B. ; Sacktor, Ned C. ; Morgello, Susan ; Simpson, David M. ; McCutchan, John A. ; Grant, Igor ; Letendre, Scott L. Less -
Description:
Background

Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIV-infected patients.

Objective

To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).

Methods

One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.

Results

FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).

Conclusions

FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.


Subject:
[+]
Adult AIDS Dementia Complex Amyloid Beta-Peptides Article Biomarkers Cerebrospinal Fluid Cross-Sectional Studies Dementia Family History Female HIV HIV Infections Humans Male Middle Aged Neurocognitive Impairment Cerebrospinal Fluid Dementia
Source:
Curr HIV Res. 14(4):324-330
Pubmed ID:
26673902
Pubmed Central ID:
PMC4916008
Document Type:
Journal Article
Funding:
U24 MH100928/MH/NIMH NIH HHSUnited States/ ; R01 NR012907/NR/NINR NIH HHSUnited States/ ; R01 DA034497/DA/NIDA NIH HHSUnited States/ ; P30 MH062512/MH/NIMH NIH HHSUnited States/ ; U01 MH083506/MH/NIMH NIH HHSUnited States/ ; ... More +
U24 MH100928/MH/NIMH NIH HHSUnited States/ ; R01 NR012907/NR/NINR NIH HHSUnited States/ ; R01 DA034497/DA/NIDA NIH HHSUnited States/ ; P30 MH062512/MH/NIMH NIH HHSUnited States/ ; U01 MH083506/MH/NIMH NIH HHSUnited States/ ; U10 NS077384/NS/NINDS NIH HHSUnited States/ ; R01 MH060720/MH/NIMH NIH HHSUnited States/ ; K99 AG048762/AG/NIA NIH HHSUnited States/ ; U01 AI035042/AI/NIAID NIH HHSUnited States/ ; R01 AG042165/AG/NIA NIH HHSUnited States/ ; R01 NS079166/NS/NINDS NIH HHSUnited States/ ; R03 DA022137/DA/NIDA NIH HHSUnited States/ ; R01 MH080150/MH/NIMH NIH HHSUnited States/ ; R01 AG034852/AG/NIA NIH HHSUnited States/ ; K24 MH097673/MH/NIMH NIH HHSUnited States/ ; P50 DA026306/DA/NIDA NIH HHSUnited States/ ; R01 MH078748/MH/NIMH NIH HHSUnited States/ ; HHSN271201000030C/MH/NIMH NIH HHSUnited States/ ; P30 MH075673/MH/NIMH NIH HHSUnited States/ ; R01 MH092225/MH/NIMH NIH HHSUnited States/ ; U2G PS000623/PS/NCHHSTP CDC HHSUnited States/ ; UM1 AI069495/AI/NIAID NIH HHSUnited States/ ; R25 MH081482/MH/NIMH NIH HHSUnited States/ ; R21 MH100968/MH/NIMH NIH HHSUnited States/ ; R01 MH058076/MH/NIMH NIH HHSUnited States/ ; HHSN271201000036C/MH/NIMH NIH HHSUnited States/ ; R01 MH078737/MH/NIMH NIH HHSUnited States/ ; R01 NS072005/NS/NINDS NIH HHSUnited States/ ; P01 DA026146/DA/NIDA NIH HHSUnited States/ ; UM1 AI035043/AI/NIAID NIH HHSUnited States/ ; R01 MH096648/MH/NIMH NIH HHSUnited States/ ; U01 AI069432/AI/NIAID NIH HHSUnited States/ ; L30 AG045921/AG/NIA NIH HHSUnited States/ ; R01 MH101017/MH/NIMH NIH HHSUnited States/ ; N01MH22005/MH/NIMH NIH HHSUnited States/ ; U13 MH081676/MH/NIMH NIH HHSUnited States/ ; U01 AI069495/AI/NIAID NIH HHSUnited States/ ; N01 MH022005/MH/NIMH NIH HHSUnited States/ ; K30 RR022681/RR/NCRR NIH HHSUnited States/ ; R01 MH083552/MH/NIMH NIH HHSUnited States/ ; R01 MH099987/MH/NIMH NIH HHSUnited States/ ; R01 MH107345/MH/NIMH NIH HHSUnited States/ ; R01 NS081196/NS/NINDS NIH HHSUnited States/ ; U24 MH100930/MH/NIMH NIH HHSUnited States/ ; R03 AG044910/AG/NIA NIH HHSUnited States/ ; R01 MH099733/MH/NIMH NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:9336f20d0ecc924289f01a441c8fbb91625a0b069d72a6badcce4e3f0d5a221b
Download URL:
https://stacks.cdc.gov/view/cdc/42126/cdc_42126_DS1.pdf
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Supporting Files

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