Details:

Alternative Title:
Drug Alcohol Depend
Publisher's site:
http://dx.doi.org/10.1016/j.drugalcdep.2015.02.019
Personal Author:
Delforterie, M. J.; Lynskey, M.; Huizink, A. C.; Creemers, H. E.; Grant, J.D.; ... More +
Delforterie, M. J.; Lynskey, M.; Huizink, A. C.; Creemers, H. E.; Grant, J.D.; Few, L. R.; Glowinski, A. L.; Statham, D. J.; Trull, T. J.; Bucholz, K. K.; Madden, P. A. F.; Martin, N. G.; Heath, A. C.; Agrawal, A.; Less -
Description:
Background In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement and psychopathology. Methods We used two community-based twin samples from the Australian Twin Registry, including 9,583 individuals (58.5% female, aged between 27 and 40). The Semi-Structured Assessment of the Genetics of Alcoholism (SSAGA) was used to assess cannabis involvement which was categorized into: (0) no cannabis use (reference category); (1) cannabis use only; (2) 1–2 cannabis use disorder symptoms; (3) 3 or more symptoms. Separate multinomial logistic regression analyses were conducted for SI and suicide attempt with or without a plan. Twin analyses examined the genetic overlap between cannabis involvement and SI. Results All levels of cannabis involvement were related to SI, regardless of duration (Odds ratios [ORs] = 1.28 – 2.00, p < 0.01). Cannabis use and endorsing ≥3 symptoms were associated with unplanned (SANP; ORs = 1.95 and 2.51 respectively, p < 0.05), but not planned suicide attempts (p > 0.10). Associations persisted even after controlling for other psychiatric disorders and substance involvement. Overlapping genetic (rG=0.45) and environmental (rE=0.21) were responsible for the covariance between cannabis involvement and SI. Conclusions Cannabis involvement is associated, albeit modestly, with SI and unplanned suicide attempts. Such attempts are difficult to prevent and their association with cannabis use and cannabis use disorder symptoms requires further study, including in different samples and with additional attention to confounders.
Subject:
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Adult
Female
Humans
Male
Marijuana Abuse
Marijuana Smoking
Suicidal Ideation
Suicide
Suicide, Attempted
Twins

Source:
Drug Alcohol Depend. 150:98-104.;
Pubmed ID:
25772435
Pubmed Central ID:
PMC4460828
Document Type:
Journal Article;
Funding:
K02 DA032573/DA/NIDA NIH HHS/United States; DA32573/DA/NIDA NIH HHS/United States; P60 AA011998/AA/NIAAA NIH HHS/United States; P50 AA011998/AA/NIAAA NIH HHS/United States; R01 AA007728/AA/NIAAA NIH HHS/United States; ... More +
K02 DA032573/DA/NIDA NIH HHS/United States; DA32573/DA/NIDA NIH HHS/United States; P60 AA011998/AA/NIAAA NIH HHS/United States; P50 AA011998/AA/NIAAA NIH HHS/United States; R01 AA007728/AA/NIAAA NIH HHS/United States; F32 AA023693/AA/NIAAA NIH HHS/United States; DA12854/DA/NIDA NIH HHS/United States; R01 DA023668/DA/NIDA NIH HHS/United States; K21 DA000272/DA/NIDA NIH HHS/United States; R56 DA012854/DA/NIDA NIH HHS/United States; R01 AA013321/AA/NIAAA NIH HHS/United States; R01 DA018267/DA/NIDA NIH HHS/United States; AA07728/AA/NIAAA NIH HHS/United States; T32 DA007313/DA/NIDA NIH HHS/United States; F32 AA013221/AA/NIAAA NIH HHS/United States; AA11998/AA/NIAAA NIH HHS/United States; AA13221/AA/NIAAA NIH HHS/United States; R01 DA012854/DA/NIDA NIH HHS/United States; R37 AA007728/AA/NIAAA NIH HHS/United States; DA18267/DA/NIDA NIH HHS/United States; T32DA007313/DA/NIDA NIH HHS/United States; R49 CE001510/CE/NCIPC CDC HHS/United States; K21DA00272/DA/NIDA NIH HHS/United States; DA23668/DA/NIDA NIH HHS/United States; Less -
Place as Subject:
Australia;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:24c58afb3aa08967c9b20983a622b898bfd5f733b0b0cbc9f06ddb3537355c31
File Type:

Supporting Files

• 	NIHMS694618-supplement-01.doc	doc
  	nihms694618.nxml	bin

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