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The relationship between cannabis involvement and suicidal thoughts and behaviors
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Details:
  • Pubmed ID:
    25772435
  • Pubmed Central ID:
    PMC4460828
  • Description:
    Background

    In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement and psychopathology.

    Methods

    We used two community-based twin samples from the Australian Twin Registry, including 9,583 individuals (58.5% female, aged between 27 and 40). The Semi-Structured Assessment of the Genetics of Alcoholism (SSAGA) was used to assess cannabis involvement which was categorized into: (0) no cannabis use (reference category); (1) cannabis use only; (2) 1–2 cannabis use disorder symptoms; (3) 3 or more symptoms. Separate multinomial logistic regression analyses were conducted for SI and suicide attempt with or without a plan. Twin analyses examined the genetic overlap between cannabis involvement and SI.

    Results

    All levels of cannabis involvement were related to SI, regardless of duration (Odds ratios [ORs] = 1.28 – 2.00, p < 0.01). Cannabis use and endorsing ≥3 symptoms were associated with unplanned (SANP; ORs = 1.95 and 2.51 respectively, p < 0.05), but not planned suicide attempts (p > 0.10). Associations persisted even after controlling for other psychiatric disorders and substance involvement. Overlapping genetic (rG=0.45) and environmental (rE=0.21) were responsible for the covariance between cannabis involvement and SI.

    Conclusions

    Cannabis involvement is associated, albeit modestly, with SI and unplanned suicide attempts. Such attempts are difficult to prevent and their association with cannabis use and cannabis use disorder symptoms requires further study, including in different samples and with additional attention to confounders.

  • Document Type:
  • Collection(s):
  • Funding:
    K02 DA032573/DA/NIDA NIH HHS/United States
    DA32573/DA/NIDA NIH HHS/United States
    P60 AA011998/AA/NIAAA NIH HHS/United States
    P50 AA011998/AA/NIAAA NIH HHS/United States
    R01 AA007728/AA/NIAAA NIH HHS/United States
    F32 AA023693/AA/NIAAA NIH HHS/United States
    DA12854/DA/NIDA NIH HHS/United States
    R01 DA023668/DA/NIDA NIH HHS/United States
    K21 DA000272/DA/NIDA NIH HHS/United States
    R56 DA012854/DA/NIDA NIH HHS/United States
    R01 AA013321/AA/NIAAA NIH HHS/United States
    R01 DA018267/DA/NIDA NIH HHS/United States
    AA07728/AA/NIAAA NIH HHS/United States
    T32 DA007313/DA/NIDA NIH HHS/United States
    F32 AA013221/AA/NIAAA NIH HHS/United States
    AA11998/AA/NIAAA NIH HHS/United States
    AA13221/AA/NIAAA NIH HHS/United States
    R01 DA012854/DA/NIDA NIH HHS/United States
    R37 AA007728/AA/NIAAA NIH HHS/United States
    DA18267/DA/NIDA NIH HHS/United States
    T32DA007313/DA/NIDA NIH HHS/United States
    R49 CE001510/CE/NCIPC CDC HHS/United States
    K21DA00272/DA/NIDA NIH HHS/United States
    DA23668/DA/NIDA NIH HHS/United States
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