Details:

Alternative Title:
Clin Endocrinol (Oxf)
Publisher's site:
http://dx.doi.org/10.1111/cen.12029
Personal Author:
Shroff, M.R. ; Holzman, C. ; Tian, Y. ; Evans, R. W. ; Sikorskii, A.
Shroff, M.R. ; Holzman, C. ; Tian, Y. ; Evans, R. W. ; Sikorskii, A. Less -
Description:
Objective

Maternal blood leptin levels are positively associated with adiposity. Recent studies suggest that leptin is also abundantly produced by the placenta and may function as a regulator of fetal growth. Our goal was to examine mid-pregnancy levels of leptin in maternal blood in relation to birthweight for gestational age (BW/GA) and timing of delivery after accounting for maternal pre-pregnancy body mass index (prepreg-BMI) and pregnancy complications.

Patients

Data were from 1,304 sub-cohort mother/infant pairs who participated in the Pregnancy Outcomes and Community Health (POUCH) Study (1998–2004).

Measurements

Leptin levels, measured at 16–27 weeks’ gestation, were log-transformed. Geometric mean (GMean) leptin levels were estimated by weighted linear regression with gestational age at blood draw as a covariate. GMean was re-transformed to the original scale for reporting.

Results

Using the GMeans leptin in mothers of term appropriate-for-gestational age (AGA) neonates as the referent (25.2 μg/L), we observed lower levels in mothers of preterm AGA (21.9 μg/L), term small-for-gestational age (SGA) (20.3 μg/L), and preterm SGA neonates (21.7 μg/L). Results were largely unchanged after adjustment for prepreg-BMI. Leptin levels were higher in mothers who delivered large-for-gestational age (LGA) neonates, both preterm (33.6 μg/L) and term (29.1 μg/L), but the GMeans were markedly attenuated after adjustment for prepreg-BMI.

Conclusion

The association between BW/GA and maternal leptin levels after adjustment for prepreg-BMI may represent: 1) a residual effect of maternal adiposity that is not fully captured by BMI; and/or 2) variation in placental leptin levels entering the maternal circulation. In conclusion, mid-pregnancy maternal blood leptin levels may be an early indicator of fetal growth status.


Subject:
[+]
Adult
Article
Birth Weight
Body Mass Index
Delivery, Obstetric
Female
Gestational Age
Humans
Infant, Newborn
Leptin
Pregnancy
Pregnancy Complications
Pregnancy Outcome
Pregnancy Trimester, Second
Premature Birth
Young Adult

Source:
Clin Endocrinol (Oxf). 78(4):607-613.
Pubmed ID:
22934578
Pubmed Central ID:
PMC4004085
Document Type:
Journal Article
Funding:
R01 HD034543/HD/NICHD NIH HHS/United States ; U01 DP000143/DP/NCCDPHP CDC HHS/United States ; R01 HD34543/HD/NICHD NIH HHS/United States
R01 HD034543/HD/NICHD NIH HHS/United States ; U01 DP000143/DP/NCCDPHP CDC HHS/United States ; R01 HD34543/HD/NICHD NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8d0420a1884a9006f7eb696233a574b4f75ad77b66e5515779f83a862d943e6f
File Type:

Supporting Files

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