Mid-pregnancy maternal leptin levels, birthweight for gestational age and preterm delivery

Details

• Alternative Title:
  Clin Endocrinol (Oxf)
• Personal Author:
  Shroff, M.R. ; Holzman, C. ; Tian, Y. ; Evans, R. W. ; Sikorskii, A.
• Description:
  Objective
  
  Maternal blood leptin levels are positively associated with adiposity. Recent studies suggest that leptin is also abundantly produced by the placenta and may function as a regulator of fetal growth. Our goal was to examine mid-pregnancy levels of leptin in maternal blood in relation to birthweight for gestational age (BW/GA) and timing of delivery after accounting for maternal pre-pregnancy body mass index (prepreg-BMI) and pregnancy complications.
  
  Patients
  
  Data were from 1,304 sub-cohort mother/infant pairs who participated in the Pregnancy Outcomes and Community Health (POUCH) Study (1998–2004).
  
  Measurements
  
  Leptin levels, measured at 16–27 weeks’ gestation, were log-transformed. Geometric mean (GMean) leptin levels were estimated by weighted linear regression with gestational age at blood draw as a covariate. GMean was re-transformed to the original scale for reporting.
  
  Results
  
  Using the GMeans leptin in mothers of term appropriate-for-gestational age (AGA) neonates as the referent (25.2 μg/L), we observed lower levels in mothers of preterm AGA (21.9 μg/L), term small-for-gestational age (SGA) (20.3 μg/L), and preterm SGA neonates (21.7 μg/L). Results were largely unchanged after adjustment for prepreg-BMI. Leptin levels were higher in mothers who delivered large-for-gestational age (LGA) neonates, both preterm (33.6 μg/L) and term (29.1 μg/L), but the GMeans were markedly attenuated after adjustment for prepreg-BMI.
  
  Conclusion
  
  The association between BW/GA and maternal leptin levels after adjustment for prepreg-BMI may represent: 1) a residual effect of maternal adiposity that is not fully captured by BMI; and/or 2) variation in placental leptin levels entering the maternal circulation. In conclusion, mid-pregnancy maternal blood leptin levels may be an early indicator of fetal growth status.
  
  
• Subjects:
  Adult Article Birth Weight Body Mass Index Delivery, Obstetric Female Gestational Age Humans Infant, Newborn Leptin Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy Trimester, Second Premature Birth Young Adult

  More +
• Source:
  Clin Endocrinol (Oxf). 78(4):607-613.
• Pubmed ID:
  22934578
• Pubmed Central ID:
  PMC4004085
• Document Type:
  Journal Article
• Funding:
  R01 HD034543/HD/NICHD NIH HHS/United States ; U01 DP000143/DP/NCCDPHP CDC HHS/United States ; R01 HD34543/HD/NICHD NIH HHS/United States
• Volume:
  78
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8d0420a1884a9006f7eb696233a574b4f75ad77b66e5515779f83a862d943e6f
• Download URL:
  https://stacks.cdc.gov/view/cdc/41954/cdc_41954_DS1.pdf
• File Type:
  [PDF - 51.80 KB ]