Alcohol consumption and breast cancer risk among postmenopausal women following the cessation of hormone therapy use: the California Teachers Study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Horn-Ross, Pamela L. ; Canchola, Alison J. ; Bernstein, Leslie ; Clarke, Christina A. ; Lacey, James V. ; Neuhausen, Susan L. ; Reynolds, Peggy ; Ursin, Giske
• Description:
  Background
  
  Alcohol consumption increases breast cancer risk, but its effect may be modified by hormone therapy (HT) use, such that exposure to both may be synergistic. Because many women stopped taking HT after mid-2002, it is important to quantify risks associated with alcohol consumption in the context of HT cessation, as these risks may be more relevant to cancer prevention efforts today.
  
  Methods
  
  Among 40,680 eligible postmenopausal California Teachers Study cohort participants, 660 were diagnosed with invasive breast cancer before 2010. Multivariate Cox proportional hazards regression models were used to estimate relative risks (RR) and 95% confidence intervals (CI).
  
  Results
  
  Increased breast cancer risk associated with alcohol consumption was observed among postmenopausal women who were current HT users (RR=1.60, 95% CI: 1.13–2.26 and RR=2.11, 95% CI: 1.41–3.15 for <20 and ≥20 g/d of alcohol), with risks being similar by HT preparation. Alcohol did not increase risk among women who had stopped using HT within 3 years or 3–4 years before completing the follow-up questionnaire or in the more distant past. Results were similar for ER+ and ER+PR+ tumors; while power was limited, no increase in risk was observed for ER- tumors.
  
  Conclusions
  
  Following the cessation of HT use, alcohol consumption is not significantly associated with breast cancer risk, although a non-significant increased risk was observed among women who never used HT.
  
  Impact
  
  Our findings confirm that concurrent exposure to HT and alcohol has a substantial adverse impact on breast cancer risk. However, after HT cessation, this risk is reduced.
  
  
• Subjects:
  Aged Aged, 80 And Over Alcohol Drinking Breast Neoplasms Cohort Studies Estrogen Replacement Therapy Female Humans Middle Aged Postmenopause Proportional Hazards Models Risk Assessment Risk Factors Surveys And Questionnaires

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 21(11):2006-2013.
• Pubmed ID:
  22832206
• Pubmed Central ID:
  PMC3721729
• Document Type:
  Journal Article
• Funding:
  HHSN261201000034C/PHS HHS/United States ; HHSN261201000036C/PHS HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000036C/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; K05 CA136967/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; R01 CA077398/CA/NCI NIH HHS/United States ; R01 CA77398/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States
• Place as Subject:
  California
• Volume:
  21
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f1d7b26dc649b80303ab0b12df4832d5e2b0610e62d0a74b4b8291ecb8c10589
• Download URL:
  https://stacks.cdc.gov/view/cdc/41898/cdc_41898_DS1.pdf
• File Type:
  [PDF - 299.44 KB ]