Prevalence of hepatitis C virus infection among human immunodeficiency virus-1-infected pregnant women in Malawi: The BAN study☆

Details

• Alternative Title:
  J Clin Virol
• Personal Author:
  Chasela, Charles S. ; Wall, Patrick ; Drobeniuc, Jan ; King, Caroline C. ; Teshale, Eyasu ; Hosseinipour, Mina C. ; Ellington, Sascha R. ; Codd, Mary ; Jamieson, Denise J. ; Knight, Rodney J. ; Fitzpatrick, Patricia ; Kourtis, Athena P. ; Hoffman, Irving F. ; Kayira, Dumbani ; Mumba, Noel ; Kamwendo, Deborah D. ; Martinson, Francis ; Powderly, William ; van der Horst, Charles ; Kamili, Saleem
• Corporate Authors:
  BAN team
• Description:
  Background
  
  In Sub-Saharan Africa, prevalence estimates of hepatitis C virus (HCV) vary widely.
  
  Objectives
  
  To assess the prevalence of HCV infection among HIV-infected, pregnant women screened for a large clinical trial in Lilongwe, Malawi.
  
  Study design
  
  Plasma from 2041 HIV-infected, pregnant women was screened for anti-HCV IgG using a chemiluminiscent immunometric assay (CIA). Specimens with a signal-cut-off ratio ≥ 1.00 were considered reactive and those with S/Co ratio < 1.00 non-reactive. All CIA-reactive specimens were tested by a recombinant immunoblot assay (RIBA) for anti-HCV and by PCR for HCV RNA.
  
  Results
  
  Of 2041 specimens, 110 (5.3%, 95% CI: 4.5–6.5%) were CIA reactive. Of the 109 CIA reactive specimens available for RIBA testing, 2 (1.8%) were positive, 28 (25.7%) were indeterminate, and 79 (72.5%) were negative. All CIA-reactive specimens were HCV RNA negative (n = 110). The estimated HCV prevalence based on the screening assay alone was 5.3%; based on supplemental RIBA testing, the status of HCV infection remained indeterminate in 1.4% (28/2040, 95% CI: 0.1–2.0) and the prevalence of confirmed HCV infections was 0.1% (2/2040, 95% CI: 0–0.4%).
  
  Conclusions
  
  HCV seroprevalence among HIV-infected, pregnant women in Malawi confirmed by supplemental RIBA HCV 3.0 is low (0.1%); CIA showed a high false-reactivity rate in this population.
  
  
• Subjects:
  Adolescent Adult Article Female Hepacivirus Hepatitis C Hepatitis C Antibodies HIV-1 HIV Infections Humans Immunoglobulin G Mass Screening Middle Aged Pregnancy Pregnancy Complications, Infectious Prevalence RNA, Viral Young Adult

  More +
• Source:
  J Clin Virol. 54(4):318-320.
• Pubmed ID:
  22658797
• Pubmed Central ID:
  PMC3652577
• Document Type:
  Journal Article
• Funding:
  U48 DP001944/DP/NCCDPHP CDC HHS/United States ; R24 TW007988/TW/FIC NIH HHS/United States ; P30-AI50410/AI/NIAID NIH HHS/United States ; U48 DP000059/DP/NCCDPHP CDC HHS/United States ; 2-D43 TW01039-06/TW/FIC NIH HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States
• Place as Subject:
  Malawi
• Volume:
  54
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2740e146b8849415c6348dca3977755d8671cac0886e18c377c5f607a9e898d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/41891/cdc_41891_DS1.pdf
• File Type:
  [PDF - 371.41 KB ]