Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma Via Up-Regulation of Myeloid-Derived Suppressor Cells

Shvedova, Anna A.; Tkach, Alexey V.; Kisin, Elena R.; Khaliullin, Timur; Stanley, Shayla; Gutkin, Dmitriy W.; Star, Alexander; Chen, Yanan; Shurin, Galina V.; Kagan, Valerian E.; Shurin, Michael R.

doi:10.1002/smll.201201470

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma Via Up-Regulation of Myeloid-Derived Suppressor Cells

5 27 2013
By Shvedova, Anna A. ; Tkach, Alexey V. ; Kisin, Elena R. ; ...
http://dx.doi.org/10.1002/smll.201201470
Source: Small. 9(0):1691-1695

[PDF-2.06 MB]

English

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Alternative Title:

Small
Personal Author:

Shvedova, Anna A. ; Tkach, Alexey V. ; Kisin, Elena R. ; Khaliullin, Timur ; Stanley, Shayla ; ... More +

Shvedova, Anna A. ; Tkach, Alexey V. ; Kisin, Elena R. ; Khaliullin, Timur ; Stanley, Shayla ; Gutkin, Dmitriy W. ; Star, Alexander ; Chen, Yanan ; Shurin, Galina V. ; Kagan, Valerian E. ; Shurin, Michael R. Less -
Description:

Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
Keywords:

[+]

Animals Bone Marrow Cells Cell Division Female Lewis Lung Carcinoma Lung Neoplasms Mice Mice, Inbred C57BL Myeloid-derived Suppressor Cells Nanotubes, Carbon SWCNT Tumor Metastasis Up-Regulation
Source:

Small. 9(0):1691-1695
Pubmed ID:

22996965
Pubmed Central ID:

PMC3624038
Document Type:

Journal Article
Funding:

R01 CA154369/CA/NCI NIH HHSUnited States/ ; R01 ES019304/ES/NIEHS NIH HHSUnited States/ ; R01 OH008282/OH/NIOSH CDC HHSUnited States/ ; R01ES019304/ES/NIEHS NIH HHSUnited States/

R01 CA154369/CA/NCI NIH HHSUnited States/ ; R01 ES019304/ES/NIEHS NIH HHSUnited States/ ; R01 OH008282/OH/NIOSH CDC HHSUnited States/ ; R01ES019304/ES/NIEHS NIH HHSUnited States/ Less -
Volume:

9
Issue:

0
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:7b66830e566cedf374b6402f01e0942ee53742ec1f3e24f162aa0b2476c4deba
Download URL:

https://stacks.cdc.gov/view/cdc/41884/cdc_41884_DS1.pdf
File Type:

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