Carbon Nanotubes Enhance Metastatic Growth of Lung Carcinoma Via Up-Regulation of Myeloid-Derived Suppressor Cells

Details

• Alternative Title:
  Small
• Personal Author:
  Shvedova, Anna A. ; Tkach, Alexey V. ; Kisin, Elena R. ; Khaliullin, Timur ; Stanley, Shayla ; Gutkin, Dmitriy W. ; Star, Alexander ; Chen, Yanan ; Shurin, Galina V. ; Kagan, Valerian E. ; Shurin, Michael R.
• Description:
  Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment.
• Keywords:
  Animals Bone Marrow Cells Cell Division Female Lewis Lung Carcinoma Lung Neoplasms Mice Mice, Inbred C57BL Myeloid-derived Suppressor Cells Nanotubes, Carbon SWCNT Tumor Metastasis Up-Regulation

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• Source:
  Small. 9(0):1691-1695
• Pubmed ID:
  22996965
• Pubmed Central ID:
  PMC3624038
• Document Type:
  Journal Article
• Funding:
  R01 CA154369/CA/NCI NIH HHSUnited States/ ; R01 ES019304/ES/NIEHS NIH HHSUnited States/ ; R01 OH008282/OH/NIOSH CDC HHSUnited States/ ; R01ES019304/ES/NIEHS NIH HHSUnited States/
• Volume:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7b66830e566cedf374b6402f01e0942ee53742ec1f3e24f162aa0b2476c4deba
• Download URL:
  https://stacks.cdc.gov/view/cdc/41884/cdc_41884_DS1.pdf
• File Type:
  [PDF - 2.06 MB ]