Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells

Details

• Personal Author:
  Chen Y ; Gutkin DW ; Kagan VE ; Khaliullin T ; Kisin ER ; Shurin GV ; Shurin MR ; Shvedova AA ; Stanley S ; Star A ; Tkach AV
• Description:
  Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotubes (SWCNT) in C57BL6/J mice. The effect is mediated by increased local and systemic accumulation of myeloid-derived suppressor cells (MDSC), as their depletion abrogated pro-tumor activity in vivo. These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment. [Description provided by NIOSH]
• Subjects:
  Immune System Lung Lung Diseases Microbiology Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Lewis Lung Carcinoma Cancer Carcinomas Cell-biology Cell-function Cellular-function Immune-reaction Immune-system Lung-cancer Lung-disease Lung-disorders Myeloid-derived Suppressor Cells Nanotechnology Surveillance-programs SWCNT Tumor Metastasis

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• ISSN:
  1613-6810
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  9
• Issue:
  9
• NIOSHTIC Number:
  nn:20041531
• Citation:
  Small 2013 May; 9(9-10):1691-1695
• Contact Point Address:
  Anna A. Shvedova, Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  ats1@cdc.gov
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Small
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:24dc9a4062377311b13df56476c9bd4a25d22f0840d39cd8d982f353160db2d6cbac02171bb4cdbe794357ba3fd01442cc2e148b4a20b5f2135c648095eeae34
• Download URL:
  https://stacks.cdc.gov/view/cdc/194074/cdc_194074_DS1.pdf
• File Type:
  [PDF - 893.35 KB ]