22622077

PMC3587032

Objective

Early infant diagnosis (EID) is the first step in HIV care, yet 75% of HIV-exposed infants born at two hospitals in Mozambique failed to access EID.

Design

Before/after study.

Setting

Two district hospitals in rural Mozambique.

Participants

HIV-infected mother/HIV-exposed infant pairs (N=791).

Intervention

We planned two phases of improvement using quality improvement methods. In Phase 1, we enhanced referral by offering direct accompaniment of new mothers to the EID suite, increasing privacy, and opening a medical record for infants prior to post-partum discharge. In Phase 2, we added enhanced referral activity as an item on the maternity register to standardize the process of referral.

Main outcome measure(s)

The proportion of HIV-infected mothers who accessed EID for their infant <90 days of life.

Results

We tracked mother/infant pairs from June 2009 to March 2011 (Phase 0: N=144; Phase 1: N=479; Phase 2: N=168), compared study measures for mother/infant pairs across intervention phases with chi-square, estimated time-to-EID by Kaplan-Meier, and determined the likelihood of EID by Cox regression after adjusting for likely barriers to follow-up. At baseline (phase 0), 25.7% of infants accessed EID <90 days. EID improved to 32.2% after Phase 1; only 17.3% received enhanced referral. After Phase 2, 61.9% received enhanced referral and 39.9% accessed EID, a significant three-phase improvement (p=0.007). In adjusted analysis, the likelihood of EID at any time was higher in the Phase 2 group vs. Phase 0 (aHR:1.68, 95%CI:1.19-2.37, p=0.003).

Conclusions

Retention improved by 55% with a simple referral enhancement. Quality improvement efforts could help improve care in Mozambique and other low-resource countries.

CDC Public Access

D43 TW001035/TW/FIC NIH HHS/United States
U2G PS000631/PS/NCHHSTP CDC HHS/United States
D43TW001035/TW/FIC NIH HHS/United States
U2GPS000631/PEPFAR/United States