Welcome to CDC stacks | Microtia-Anotia: A Global Review of Prevalence Rates - 41864 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Microtia-Anotia: A Global Review of Prevalence Rates
Filetype[PDF-768.68 KB]


Details:
  • Pubmed ID:
    21656661
  • Pubmed Central ID:
    PMC3405852
  • Description:
    Background

    There are few published studies on microtia-anotia frequency.

    Methods

    Using data from birth defects surveillance programs around the world, we conducted a systematic review on the frequency of microtia-anotia to further explore the differences in prevalence across countries. Ninety-two birth defects surveillance programs were evaluated with a total of 8,917 cases of microtia-anotia. We computed the prevalence per 10,000 births for each surveillance program for total cases of microtia-anotia (microtia types I to IV), microtia (types I to III), and anotia (type IV). Prevalence ratios were calculated by large geographical areas, race/ethnicity, and by surveillance methodologies.

    Results

    The overall prevalence were for microtia-anotia 2.06 (CI: 2.02–2.10), for microtia 1.55 (CI: 1.50–1.60), and for anotia 0.36 (CI: 0.34–0.38). Higher prevalence was observed in the Americas, Northern Europe and Asia, among Hispanics and Asians, and among active ascertainment and hospital-based surveillance programs.

    Conclusions

    We observed marked variation in the prevalence of microtia-anotia across surveillance programs and within countries. These results must be interpreted cautiously as this variability may be explained mainly by differences in surveillance methods. However, given the magnitude of some of the differences, other factors may also be involved. This study contributes to the knowledge on the prevalence of microtia-anotia by providing a critical analysis of the existing data. In addition, it supports the need for a coding system that allows complete phenotype characterization of microtia-anotia, including severity and laterality; as well as further studies on the variation of its frequency related to race and ethnicity.

  • Document Type:
  • Collection(s):
  • Funding:
    K99 DC011282/DC/NIDCD NIH HHS/United States
    U50 DD000524/DD/NCBDD CDC HHS/United States
No Related Documents.
You May Also Like: