Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Details

• Alternative Title:
  Nat Genet
• Personal Author:
  Haiman, Christopher A. ; Chen, Gary K. ; Blot, William J. ; Strom, Sara S. ; Berndt, Sonja I. ; Kittles, Rick A. ; Rybicki, Benjamin A. ; Isaacs, William ; Ingles, Sue A. ; Stanford, Janet L. ; Diver, W. Ryan ; Witte, John S. ; Hsing, Ann W. ; Nemesure, Barbara ; Rebbeck, Timothy R. ; Cooney, Kathleen A. ; Xu, Jianfeng ; Kibel, Adam S. ; Hu, Jennifer J. ; John, Esther M. ; Gueye, Serigne M. ; Watya, Stephen ; Signorello, Lisa B. ; Hayes, Richard B. ; Wang, Zhaoming ; Yeboah, Edward ; Tettey, Yao ; Cai, Qiuyin ; Kolb, Suzanne ; Ostrander, Elaine A. ; Zeigler-Johnson, Charnita ; Yamamura, Yuko ; Neslund-Dudas, Christine ; Haslag-Minoff, Jennifer ; Wu, William ; Thomas, Venetta ; Allen, Glenn O. ; Murphy, Adam ; Chang, Bao-Li ; Zheng, S. Lilly ; Leske, M. Cristina ; Wu, Suh-Yuh ; Ray, Anna M. ; Hennis, Anselm JM ; Thun, Michael J. ; Carpten, John ; Casey, Graham ; Carter, Erin N. ; Duarte, Edder R. ; Xia, Lucy Y. ; Sheng, Xin ; Wan, Peggy ; Pooler, Loreall C. ; Cheng, Iona ; Monroe, Kristine R. ; Schumacher, Fredrick ; Le Marchand, Loic ; Kolonel, Laurence N. ; Chanock, Stephen J. ; Van Den Berg, David ; Stram, Daniel O. ; Henderson, Brian E.
• Description:
  In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.
• Subjects:
  Black Or African American Chromosomes, Human, Pair 17 Genetic Predisposition To Disease Genome-Wide Association Study Humans Male Polymorphism, Single Nucleotide Prostatic Neoplasms
• Source:
  Nat Genet. 43(6):570-573.
• Pubmed ID:
  21602798
• Pubmed Central ID:
  PMC3102788
• Document Type:
  Journal Article
• Funding:
  ES011126/ES/NIEHS NIH HHS/United States ; CA54281/CA/NCI NIH HHS/United States ; CA105641/CA/NCI NIH HHS/United States ; RC2 CA148085/CA/NCI NIH HHS/United States ; ES007784/ES/NIEHS NIH HHS/United States ; CA88164/CA/NCI NIH HHS/United States ; CA127298/CA/NCI NIH HHS/United States ; CA092579/CA/NCI NIH HHS/United States ; HG004726-01/HG/NHGRI NIH HHS/United States ; CA1326792/CA/NCI NIH HHS/United States ; P50 CA140388/CA/NCI NIH HHS/United States ; CA136792-01/CA/NCI NIH HHS/United States ; CA114379/CA/NCI NIH HHS/United States ; RC2 CA148085-01/CA/NCI NIH HHS/United States ; U01 CA127298/CA/NCI NIH HHS/United States ; R01 CA092447/CA/NCI NIH HHS/United States ; R01 CA112028/CA/NCI NIH HHS/United States ; CA148085-01/RC/CCR NIH HHS/United States ; CA056678/CA/NCI NIH HHS/United States ; R01 CA068578/CA/NCI NIH HHS/United States ; HG004726/HG/NHGRI NIH HHS/United States ; CA68578/CA/NCI NIH HHS/United States ; R01 CA056678/CA/NCI NIH HHS/United States ; CA63464/CA/NCI NIH HHS/United States ; CA082664/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; Intramural NIH HHS/United States ; U19 CA148537/CA/NCI NIH HHS/United States ; CA148085/CA/NCI NIH HHS/United States ; R01 CA063464/CA/NCI NIH HHS/United States ; R01 CA085074/CA/NCI NIH HHS/United States ; CA085074/CA/NCI NIH HHS/United States ; N01-HG-25487/HG/NHGRI NIH HHS/United States ; R01 CA082664/CA/NCI NIH HHS/United States ; U01 HG004726-01/HG/NHGRI NIH HHS/United States ; P30 ES007784/ES/NIEHS NIH HHS/United States ; R01 CA054281/CA/NCI NIH HHS/United States ; U01 CA063464/CA/NCI NIH HHS/United States ; P50 CA105641/CA/NCI NIH HHS/United States ; P30 CA068485/CA/NCI NIH HHS/United States ; R01 CA088164/CA/NCI NIH HHS/United States ; CA140388/CA/NCI NIH HHS/United States ; CA092447/CA/NCI NIH HHS/United States ; CA68485/CA/NCI NIH HHS/United States ; S06 GM008016/GM/NIGMS NIH HHS/United States ; R01 ES011126/ES/NIEHS NIH HHS/United States ; U01 CA136792-01/CA/NCI NIH HHS/United States ; R01 CA092579/CA/NCI NIH HHS/United States ; U01 CA136792/CA/NCI NIH HHS/United States ; N01PC35139/CA/NCI NIH HHS/United States ; R37 CA054281/CA/NCI NIH HHS/United States ; CA112028/CA/NCI NIH HHS/United States ; S06GM08016/GM/NIGMS NIH HHS/United States ; U01 HG004726/HG/NHGRI NIH HHS/United States
• Volume:
  43
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:13799817592e0919ef1036765ee3511fc8968f72ed7f0888d16fdb0264af0c67
• Download URL:
  https://stacks.cdc.gov/view/cdc/41834/cdc_41834_DS1.pdf
• File Type:
  [PDF - 535.08 KB ]