Determinants of optimal adherence over time to antiretroviral therapy amongst HIV positive adults in South Africa: A longitudinal study

Details

• Alternative Title:
  AIDS Behav
• Personal Author:
  Maqutu, Dikokole ; Zewotir, Temesgen ; North, Delia ; Naidoo, Kogieleum ; Grobler, Anneke
• Description:
  Highly active antiretroviral therapy (HAART) requires strict adherence to achieve optimal clinical and survival benefits. A study was done to explore the factors affecting HAART adherence among HIV positive adults by reviewing routinely collected patient information in the Centre for the AIDS Programme of Research in South Africa's (CAPRISA) AIDS Treatment Programme. Records of 688 patients enrolled between 2004 and 2006 were analysed. Patients were considered adherent if they had taken at least 95% of their prescribed drugs. Generalized estimating equations were used to analyse the data. The results showed that HAART adherence increased over time, however, the rate of increase differed by some of the socio-demographic and behavioural characteristics of the patients. For instance, HAART adherence increased in both urban and rural treatment sites over time, but the rate of increase was higher in the rural site. This helped identify sub-populations, such as the urban population, that required ongoing adherence counseling.
• Subjects:
  Adult Antiretroviral Therapy, Highly Active Article Female Follow-Up Studies HIV Infections Humans Longitudinal Studies Male Medication Adherence Middle Aged Retrospective Studies Rural Population Sex Distribution Sex Factors Socioeconomic Factors Time Factors Treatment Outcome Urban Population Young Adult

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• Source:
  AIDS Behav. 15(7):1465-1474.
• Pubmed ID:
  20352319
• Pubmed Central ID:
  PMC3056165
• Document Type:
  Journal Article
• Funding:
  D43TW00231/TW/FIC NIH HHS/United States ; U19 AI051794-05/AI/NIAID NIH HHS/United States ; D43 TW000231-17/TW/FIC NIH HHS/United States ; D43 TW000231/TW/FIC NIH HHS/United States ; AI51794/AI/NIAID NIH HHS/United States ; U19 AI051794/AI/NIAID NIH HHS/United States ; U2G PS001350/PS/NCHHSTP CDC HHS/United States
• Place as Subject:
  South Africa
• Volume:
  15
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2598794b517715eade6e17e7470688f983b33cec9b41992ab37352f103f9c5d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/41825/cdc_41825_DS1.pdf
• File Type:
  [PDF - 1.54 MB ]