Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa

Details

• Alternative Title:
  Genome Announc
• Personal Author:
  Mentoor, Juliet L. D. ; Lubisi, Alison B. ; Gerdes, Truuska ; Human, Stacey ; Williams, June H. ; Venter, Marietjie
• Description:
  We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence.
• Subjects:
  Viruses
• Source:
  Genome Announc. 2016; 4(4).
• Pubmed ID:
  27469963
• Pubmed Central ID:
  PMC4966467
• Document Type:
  Journal Article
• Volume:
  4
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ea2e9a40bae0ec8b2fea456749dd1dff1311a4f71c614c785c16df6370c23a24
• Download URL:
  https://stacks.cdc.gov/view/cdc/41581/cdc_41581_DS1.pdf
• File Type:
  [PDF - 142.67 KB ]