Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa

Mentoor, Juliet L. D.; Lubisi, Alison B.; Gerdes, Truuska; Human, Stacey; Williams, June H.; Venter, Marietjie

doi:10.1128/genomeA.00740-16

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Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa

Published Date:

Jul 28 2016

Publisher's site:

http://dx.doi.org/10.1128/genomeA.00740-16 New Site Icon

Source:

Genome Announc. 2016; 4(4).

[PDF-142.67 KB]

Details:

Personal Authors:

Mentoor, Juliet L. D. ; Lubisi, Alison B. ; Gerdes, Truuska ; Human, Stacey ; Williams, June H. ; ... More ▼

Keywords:

[+]

Pubmed ID:

27469963

Pubmed Central ID:

PMC4966467

Description:

We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Supporting Files:

e00740-16.nxml

application/octet-stream

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