Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021–June 2023

Almendares, Olivia; Baker, Julia M.; Sugerman, David E.; Parashar, Umesh D.; Reagan-Steiner, Sarah; Kirking, Hannah L.; Gastañaduy, Paul A.; Tate, Jacqueline E.

doi:10.3201/eid3004.231140

i

Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021–June 2023

Supporting Files Public Domain

4 2024
By Almendares, Olivia ; Baker, Julia M. ; Sugerman, David E. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Almendares, Olivia ; Baker, Julia M. ; Sugerman, David E. ; Parashar, Umesh D. ; Reagan-Steiner, Sarah ; Kirking, Hannah L. ; Gastañaduy, Paul A. ; Tate, Jacqueline E.
Corporate Authors:

Hepatitis of Unknown Etiology Group2
Description:

During October 2021-June 2023, a total of 392 cases of acute hepatitis of unknown etiology in children in the United States were reported to Centers for Disease Control and Prevention as part of national surveillance. We describe demographic and clinical characteristics, including potential involvement of adenovirus in development of acute hepatitis, of 8 fatally ill children who met reporting criteria. The children had diverse courses of illness. Two children were immunocompromised when initially brought for care. Four children tested positive for adenovirus in multiple specimen types, including 2 for whom typing was completed. One adenovirus-positive child had no known underlying conditions, supporting a potential relationship between adenovirus and acute hepatitis in previously healthy children. Our findings emphasize the importance of continued investigation to determine the mechanism of liver injury and appropriate treatment. Testing for adenovirus in similar cases could elucidate the role of the virus.
Subjects:

Acute Disease Child Hepatitis Hepatitis A Humans Viruses
Keywords:

Acute Disease Adenovirus Infections Bacteria Burkholderia Pseudomallei Child Fatal Outcome Hepatitis History Melioidosis United States Viruses
Source:

Emerg Infect Dis. 2024; 30(4):644-653
Pubmed ID:

38526164
Pubmed Central ID:

PMC10977843
Document Type:

Journal Article
Place as Subject:

United States
Volume:

30
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:3676b166be4073a7572a293bbc20be13edf23ab5c235e796649a459eb69b0ddd
Download URL:

https://stacks.cdc.gov/view/cdc/152954/cdc_152954_DS1.pdf
File Type:

[PDF - 1.13 MB ]

File Language:

English

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