Ebola Virus Disease, Democratic Republic of the Congo, 2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nanclares, Carolina ; Kapetshi, Jimmy ; Lionetto, Fanshen ; de la Rosa, Olimpia ; Tamfun, Jean-Jacques Muyembe ; Alia, Miriam ; Kobinger, Gary ; Bernasconi, Andrea
• Description:
  During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool Disease Outbreaks Ebolavirus Female Hemorrhagic Fever, Ebola/Epidemiology Hemorrhagic Fever, Ebola/History Hemorrhagic Fever, Ebola/Mortality Hemorrhagic Fever, Ebola/Virology History, 21St Century Humans Infant Kaplan-Meier Estimate Male Middle Aged Proportional Hazards Models Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Rna, Viral Young Adult

  More +
• Source:
  Emerg Infect Dis. 22(9):1579-1586.
• Pubmed ID:
  27533284
• Pubmed Central ID:
  PMC4994351
• Document Type:
  Journal Article
• Place as Subject:
  Democratic Republic of the Congo
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:fabb095ec9fdc2afa7492df03466facfbe9acd8d968e7f2589345f8db1dfcf25
• Download URL:
  https://stacks.cdc.gov/view/cdc/41265/cdc_41265_DS1.pdf
• File Type:
  [PDF - 605.93 KB ]