Mutation in West Nile Virus Structural Protein prM during Human Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lustig, Yaniv ; Lanciotti, Robert S. ; Hindiyeh, Musa ; Keller, Nathan ; Milo, Ron ; Mayan, Shlomo ; Mendelson, Ella
• Description:
  A mutation leading to substitution of a key amino acid in the prM protein of West Nile virus (WNV) occurred during persistent infection of an immunocompetent patient. WNV RNA persisted in the patient's urine and serum in the presence of low-level neutralizing antibodies. This case demonstrates active replication of WNV during persistent infection.
• Subjects:
  Antibodies, Neutralizing Antibodies, Viral Dispatch Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin G Immunoglobulin M Male Middle Aged Mutation Phylogeny Rna, Viral Viral Load Viral Structural Proteins West Nile Fever Whole Genome Sequencing

  More +
• Source:
  Emerg Infect Dis. 22(9):1647-1649.
• Pubmed ID:
  27322782
• Pubmed Central ID:
  PMC4994336
• Document Type:
  Journal Article
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5f7e1a633b45d22d8999a63f315a0c4ba764c4f49e37bb309e9b4d3157f9e112
• Download URL:
  https://stacks.cdc.gov/view/cdc/41257/cdc_41257_DS1.pdf
• File Type:
  [PDF - 377.51 KB ]