Communities

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Baker, Kate S. ; Dallman, Timothy J. ; Behar, Adi ; Weill, François-Xavier ; Gouali, Malika ; Sobel, Jeremy ; Fookes, Maria ; Valinsky, Lea ; Gal-Mor, Ohad ; Connor, Thomas R. ; Nissan, Israel ; Bertrand, Sophie ; Parkhill, Julian ; Jenkins, Claire ; Cohen, Dani ; Thomson, Nicholas R.
• Description:
  Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug-resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.
• Subjects:
  Anti-Bacterial Agents/pharmacology Anti-Bacterial Agents/therapeutic Use Community-Acquired Infections/epidemiology Community-Acquired Infections/history Community-Acquired Infections/microbiology Community-Acquired Infections/transmission Disease Outbreaks Drug Resistance, Multiple, Bacterial Dysentery, Bacillary/epidemiology Dysentery, Bacillary/history Dysentery, Bacillary/microbiology Dysentery, Bacillary/transmission Genes, Bacterial Genome, Bacterial Global Health History, 20th Century History, 21st Century Humans Jews Microbial Sensitivity Tests Population Surveillance Research Risk Factors Shigella Sonnei Travel

  More +
• Source:
  Emerg Infect Dis. 22(9):1545-1553.
• Pubmed ID:
  27532625
• Pubmed Central ID:
  PMC4994374
• Document Type:
  Journal Article
• Place as Subject:
  Israel ; Europe ; France ; Belgium ; United States ; Canada
• Location:
  Middle East ; Europe ; North America
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:41ff6ad11d4fba112fd93231e4f1a71f729bd12e9be61910d72d91cc5e0b85fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/41246/cdc_41246_DS1.pdf
• File Type:
  [PDF - 985.66 KB ]