Clinical Features of and Risk Factors for Fatal Ebola Virus Disease, Moyamba District, Sierra Leone, December 2014–February 2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Haaskjold, Yngvar Lunde ; Bolkan, Håkon Angell ; Krogh, Kurt Østhuus ; Jongopi, James ; Lundeby, Karen Marie ; Mellesmo, Sindre ; Garcés, Pedro San José ; Jøsendal, Ola ; Øpstad, Åsmund ; Svensen, Erling ; Fuentes, Luis Matias Zabala ; Kamara, Alfred Sandy ; Riera, Melchor ; Arranz, Javier ; Roberts, David P. ; Stamper, Paul D. ; Austin, Paula ; Moosa, Alfredo J. ; Marke, Dennis ; Hassan, Shoaib ; Eide, Geir Egil ; Berg, Åse ; Blomberg, Bjørn
• Description:
  The 2013-2016 outbreak of Ebola virus disease (EVD) in West Africa infected >28,000 people, including >11,000 who died, and disrupted social life in the region. We retrospectively studied clinical signs and symptoms and risk factors for fatal outcome among 31 Ebola virus-positive patients admitted to the Ebola Treatment Center in Moyamba District, Sierra Leone. We found a higher rate of bleeding manifestations than reported elsewhere during the outbreak. Significant predictors for death were shorter time from symptom onset to admission, male sex, high viral load on initial laboratory testing, severe pain, diarrhea, bloody feces, and development of other bleeding manifestations during hospitalization. These risk factors for death could be used to identify patients in need of more intensive medical support. The lack of fever in as many as one third of EVD cases may have implications for temperature-screening practices and case definitions.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Disease Outbreaks Female Hemorrhagic Fever, Ebola/Diagnosis Hemorrhagic Fever, Ebola/Epidemiology Hemorrhagic Fever, Ebola/History Hemorrhagic Fever, Ebola/Virology History, 21St Century Humans Infant Infectious Disease Incubation Period Male Middle Aged Mortality Population Surveillance Retrospective Studies Symptom Assessment Viral Load Young Adult

  More +
• Source:
  Emerg Infect Dis. 22(9):1537-1544.
• Pubmed ID:
  27268303
• Pubmed Central ID:
  PMC4994367
• Document Type:
  Journal Article
• Place as Subject:
  Sierra Leone
• Volume:
  22
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:24c1126c982ec1742dbe8900aa50dfaa5adf2f7feeb8dc50c92bca39b349ac4e
• Download URL:
  https://stacks.cdc.gov/view/cdc/41243/cdc_41243_DS1.pdf
• File Type:
  [PDF - 514.52 KB ]