Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands

van der Sanden, Sabine M.G.; Koen, Gerrit; van Eijk, Hetty; Koekkoek, Sylvie M.; de Jong, Menno D.; Wolthers, Katja C.

doi:10.3201/eid2209.151579

i

Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands

Supporting Files Public Domain

Sep 2016
By van der Sanden, Sabine M.G. ; Koen, Gerrit ; van Eijk, Hetty ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

van der Sanden, Sabine M.G. ; Koen, Gerrit ; van Eijk, Hetty ; Koekkoek, Sylvie M. ; de Jong, Menno D. ; Wolthers, Katja C.
Description:

Outbreaks of human enterovirus 71 (EV-71) in Asia are related to high illness and death rates among children. To gain insight into the potential threat for the population of Europe, we determined the neutralizing activity in intravenous immunoglobulin (IVIg) batches and individual serum samples from donors in the Netherlands against EV-71 strains isolated in Europe and in Asia. All IVIg batches and 41%, 79%, and 65% of serum samples from children ≤5 years of age, women of childbearing age, and HIV-positive men, respectively, showed high neutralizing activity against a Dutch C1 strain, confirming widespread circulation of EV-71 in the Netherlands. Asian B3-4 and C4 strains were efficiently cross-neutralized, predicting possible protection against extensive circulation and associated outbreaks of those types in Europe. However, C2 and C5 strains that had few mutations in the capsid region consistently escaped neutralization, emphasizing the importance of monitoring antigenic diversity among circulating EV-71 strains.
Subjects:

Adult Animals Antibodies, Neutralizing Antibodies, Viral Capsid Proteins Cell Line Child, Preschool Coinfection Cross Protection Disease Outbreaks Enterovirus A, Human Enterovirus Infections Female Genotype Hiv Infections Humans Immunoglobulins, Intravenous Infant Infant, Newborn Male Middle Aged Neutralization Tests Population Surveillance Seroepidemiologic Studies Viral Plaque Assay Young Adult
Source:

Emerg Infect Dis. 22(9):1562-1569.
Pubmed ID:

27533024
Pubmed Central ID:

PMC4994357
Document Type:

Journal Article
Place as Subject:

Netherlands
Volume:

22
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:0b2ded1eab816c79a35feb8ab41aa8e7392125a0aaea7dd24b8751aeb0ad3df8
Download URL:

https://stacks.cdc.gov/view/cdc/41242/cdc_41242_DS1.pdf
File Type:

[PDF - 1.04 MB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.