Post-9/11 cancer incidence in World Trade Center-exposed New York City firefighters as compared to a pooled cohort of firefighters from San Francisco, Chicago and Philadelphia (9/11/2001-2009)

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Moir, William ; Zeig-Owens, Rachel ; Daniels, Robert D. ; Hall, Charles B ; Webber, Mayris P. ; Jaber, Nadia ; Yiin, James H. ; Schwartz, Theresa ; Liu, Xiaoxue ; Vossbrinck, Madeline ; Kelly, Kerry ; Prezant, David J.
• Description:
  Background
  
  We previously reported a modest excess of cancer cases in World Trade Center (WTC) exposed firefighters as compared with the general population. This study aimed to separate the potential carcinogenic effects of firefighting and WTC-exposure by using a cohort of non-WTC-exposed firefighters as the referent group.
  
  Methods
  
  Relative rates (RRs) for all cancers combined and individual cancer subtypes from 9/11/2001-12/31/2009 were modelled using Poisson regression comparing 11,457 WTC-exposed firefighters to 8,220 non-WTC-exposed firefighters from San Francisco, Chicago, and Philadelphia.
  
  Results
  
  Compared with non-WTC-exposed firefighters, there was no difference in the RR of all cancers combined for WTC-exposed firefighters (RR=0.96, 95% CI: 0.83–1.12). Thyroid cancer was significantly elevated (RR=3.82, 95% CI: 1.07–20.81) over the entire study; this was attenuated (RR=3.43, 95% CI: 0.94–18.94) and non-significant in a secondary analysis controlling for possible surveillance bias. Prostate cancer was elevated during the latter half (1/1/2005-12/31/2009; RR=1.38, 95% CI: 1.01–1.88).
  
  Conclusions
  
  Further follow-up is needed with this referent population to assess the relationship between WTC-exposure and cancers with longer latency periods.
  
  
• Subjects:
  Article Cancer Environmental Disaster Epidemiology Firefighters World Trade Center (WTC)
• Source:
  Am J Ind Med. 59(9):722-730.
• Pubmed ID:
  27582474
• Pubmed Central ID:
  PMC5010035
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; UL1 TR001073/TR/NCATS NIH HHS/United States
• Volume:
  59
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d4aa47bb2b61e6ca1d6b1a93c0f6c44265e2dd4ce29e553b2fdd6c770e045136
• Download URL:
  https://stacks.cdc.gov/view/cdc/41195/cdc_41195_DS1.pdf
• File Type:
  [PDF - 92.67 KB ]