Drug-Induced Hypothyroidism during Anti-Tuberculosis Treatment of Multidrug-Resistant Tuberculosis: Notes from the Field

Munivenkatappa, Somashekar; Anil, Singarajipura; Naik, Balaji; Volkmann, Tyson; Sagili, Karuna D.; Akshatha, Jayachamarajapura S.; Buggi, Shashidhar; Sharada, Manchenahalli A.; Kulkarni, Sudhendra; Chadha, Vineet K.; Moonan, Patrick K.

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Drug-Induced Hypothyroidism during Anti-Tuberculosis Treatment of Multidrug-Resistant Tuberculosis: Notes from the Field

Supporting Files

Aug 23 2016
By Munivenkatappa, Somashekar ; Anil, Singarajipura ; Naik, Balaji ; ...

File Language:

English

Details

Alternative Title:

J Tuberc Res
Journal Article:

MMWR Morb Mortal Wkly Rep
Personal Author:

Munivenkatappa, Somashekar ; Anil, Singarajipura ; Naik, Balaji ; Volkmann, Tyson ; Sagili, Karuna D. ; Akshatha, Jayachamarajapura S. ; Buggi, Shashidhar ; Sharada, Manchenahalli A. ; Kulkarni, Sudhendra ; Chadha, Vineet K. ; Moonan, Patrick K.
Description:

We followed 188 euthyroidic persons undergoing treatment for multidrug resistant tuberculosis (MDR-TB) in the state of Karnataka, India to determine the incidence of hypothyroidism during anti-tuberculosis treatment. Overall, among MDR-TB patients with valid thyroid stimulating hormone (TSH) values, about 23% developed hypothyroidism (TSH value ≥10 mIU/ml) during anti-tuberculosis treatment; the majority (74%) occurring after 3 months of treatment. Among 133 patients who received a regimen that contained ethionamide, 42 (32%) developed hypothyroidism. Among 17 patients that received a regimen that contained para-aminosalicylate sodium, 6 (35%) developed hypothyroidism. Among 9 HIV positive patients on anti-retroviral treatment, 4 (44%) developed hypothyroidism. These results differ from previously reported 4% incidence of hypothyroidism amongst patients who passively reported thyroidal symptoms during treatment, suggesting routine serologic monitoring of TSH throughout the course of treatment for MDR-TB is warranted.
Subjects:

Article Hypothyroidism Multidrug Resistance Thyroid-Stimulating Hormone Tuberculosis
Source:

J Tuberc Res. 4(3):105-110.
Pubmed ID:

27595122
Pubmed Central ID:

PMC5007858
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Place as Subject:

India
Volume:

4
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha-512:e9042762cda7a478adc2eba4027b4614f84fe7adde86016bc329970bfec5adbdcea15e3732ac83fa77b035c8e24be6c52d097cf640b3c5681cd4473ce138047d
Download URL:

https://stacks.cdc.gov/view/cdc/41188/cdc_41188_DS1.pdf
File Type:

[PDF - 56.04 KB ]

nihms812796.nxml

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File Language:

English

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