Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt, Sonja I.; Camp, Nicola J.; Skibola, Christine F.; Vijai, Joseph; Wang, Zhaoming; Gu, Jian; Nieters, Alexandra; Kelly, Rachel S.; Smedby, Karin E.; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia S.; Lan, Qing; Teras, Lauren R.; Machado, Moara; Yeager, Meredith; Brooks-Wilson, Angela R.; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda M.; Vajdic, Claire M.; Cocco, Pierluigi; Zhang, Yawei; Giles, Graham G.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Montalvan, Rebecca; Burdett, Laurie; Hutchinson, Amy; Ye, Yuanqing; Call, Timothy G.; Shanafelt, Tait D.; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Cunningham, Julie M.; Allmer, Cristine; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa A.; Diver, W Ryan; Link, Brian K.; Weiner, George J.; Conde, Lucia; Bracci, Paige M.; Riby, Jacques; Arnett, Donna K.; Zhi, Degui; Leach, Justin M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Sala, Núria; Casabonne, Delphine; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Chaffee, Kari G.; Achenbach, Sara J.; Vachon, Celine M.; Goldin, Lynn R.; Strom, Sara S.; Leis, Jose F.; Weinberg, J. Brice; Caporaso, Neil E.; Norman, Aaron D.; De Roos, Anneclaire J.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Masala, Giovanna; Weiderpass, Elisabete; Chirlaque, María- Dolores; Vermeulen, Roel C. H.; Travis, Ruth C.; Southey, Melissa C.; Milne, Roger L.; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Clavel, Jacqueline; Zheng, Tongzhang; Holford, Theodore R.; Villano, Danylo J.; Maria, Ann; Spinelli, John J.; Gascoyne, Randy D.; Connors, Joseph M.; Bertrand, Kimberly A.; Giovannucci, Edward; Kraft, Peter; Kricker, Anne; Turner, Jenny; Ennas, Maria Grazia; Ferri, Giovanni M.; Miligi, Lucia; Liang, Liming; Ma, Baoshan; Huang, Jinyan; Crouch, Simon; Park, Ju-Hyun; Chatterjee, Nilanjan; North, Kari E.; Snowden, John A.; Wright, Josh; Fraumeni, Joseph F.; Offit, Kenneth; Wu, Xifeng; de Sanjose, Silvia; Cerhan, James R.; Chanock, Stephen J.; Rothman, Nathaniel; Slager, Susan L.

doi:10.1038/ncomms10933

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Published Date:

Mar 09 2016

Publisher's site:

http://dx.doi.org/10.1038/ncomms10933 New Site Icon

Source:

Nat Commun. 2016; 7.

[PDF-1.02 MB]

Details:

Personal Authors:

Berndt, Sonja I. ; Camp, Nicola J. ; Skibola, Christine F. ; Vijai, Joseph ; Wang, Zhaoming ; ... More ▼

Keywords:

[+]

Pubmed ID:

26956414

Pubmed Central ID:

PMC4786871

Description:

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Main Document Checksum:

[+]

Supporting Files:

	ncomms10933-f1.gif	image/gif
	ncomms10933-f1.jpg	image/jpeg
	ncomms10933-f2.gif	image/gif
	ncomms10933-f2.jpg	image/jpeg
	ncomms10933-i1.jpg	image/jpeg
	ncomms10933-s1.pdf	application/pdf
	ncomms10933.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

Personal Author:

Law, Philip J.; Berndt, Sonja I.; Speedy, Helen E.; Camp, Nicola J.; Sava, Georgina P.; Skibola, Christine F.; Holroyd, Amy; Joseph, Vijai; Sunter, Nicola J.; Nieters, Alexandra; Bea, Silvia; Monnereau, Alain; Martin-Garcia, David; Goldin, Lynn R.; Clot, Guillem; Teras, Lauren R.; Quintela, Inés; Birmann, Brenda M.; Jayne, Sandrine; Cozen, Wendy; Majid, Aneela; Smedby, Karin E.; Lan, Qing; Dearden, Claire; Brooks-Wilson, Angela R.; Hall, Andrew G.; Purdue, Mark P.; Mainou-Fowler, Tryfonia; Vajdic, Claire M.; Jackson, Graham H.; Cocco, Pierluigi; Marr, Helen; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham G.; Lawrence, Charles; Call, Timothy G.; Liebow, Mark; Melbye, Mads; Glimelius, Bengt; Mansouri, Larry; Glenn, Martha; Curtin, Karen; Diver, W Ryan; Link, Brian K.; Conde, Lucia; Bracci, Paige M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Maynadie, Marc; McKay, James; Albanes, Demetrius; Weinstein, Stephanie; Wang, Zhaoming; Caporaso, Neil E.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Vermeulen, Roel C. H.; Southey, Melissa C.; Milne, Roger L.; Clavel, Jacqueline; Topka, Sabine; Spinelli, John J.; Kraft, Peter; Ennas, Maria Grazia; Summerfield, Geoffrey; Ferri, Giovanni M.; Harris, Robert J.; Miligi, Lucia; Pettitt, Andrew R.; North, Kari E.; Allsup, David J.; Fraumeni, Joseph F.; Bailey, James R.; Offit, Kenneth; Pratt, Guy; Hjalgrim, Henrik; Pepper, Chris; Chanock, Stephen J.; Fegan, Chris; Rosenquist, Richard; de Sanjose, Silvia; Carracedo, Angel; Dyer, Martin J. S.; Catovsky, Daniel; Campo, Elias; Cerhan, James R.; Allan, James M.; Rothman, Nathanial; Houlston, Richard; Slager, Susan;

Published:

Feb 06 2017

Source:

Nat Commun. 2017; 8.

Description:

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference pan...

File Type:

[PDF - 953.20 KB]
HLA class I and II diversity contributes to the etiologic heterogeneity of non-Hodgkin lymphoma subtypes

Personal Author:

Wang, Sophia S.; Carrington, Mary; Berndt, Sonja I.; Slager, Susan L.; Bracci, Paige M.; Voutsinas, Jenna; Cerhan, James R.; Smedby, Karin E.; Hjalgrim, Henrik; Vijai, Joseph; Morton, Lindsay M.; Vermeulen, Roel; Paltiel, Ora; Vajdic, Claire M.; Linet, Martha S.; Nieters, Alexandra; de Sanjose, Silvia; Cozen, Wendy; Brown, Elizabeth E.; Turner, Jennifer; Spinelli, John J.; Zheng, Tongzhang; Birmann, Brenda M.; Flowers, Christopher R.; Becker, Nikolaus; Holly, Elizabeth A.; Kane, Eleanor; Weisenburger, Dennis; Maynadie, Marc; Cocco, Pierluigi; Albanes, Demetrius; Weinstein, Stephanie J.; Teras, Lauren R.; Diver, W. Ryan; Lax, Stephanie J.; Travis, Ruth C.; Kaaks, Rudolph; Riboli, Elio; Benavente, Yolanda; Brennan, Paul; McKay, James; Delfau-Larue, Marie-Hélène; Link, Brian K.; Magnani, Corrado; Ennas, Maria Grazia; Latte, Giancarlo; Feldman, Andrew L.; Doo, Nicole Wong; Giles, Graham G.; Southey, Melissa C.; Milne, Roger L.; Offit, Kenneth; Musinsky, Jacob; Arslan, Alan A.; Purdue, Mark P.; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Conde, Lucia; Camp, Nicola J.; Glenn, Martha; Curtin, Karen; Clavel, Jacqueline; Monnereau, Alain; Cox, David G.; Ghesquières, Hervé; Salles, Gilles; Bofetta, Paulo; Foretova, Lenka; Staines, Anthony; Davis, Scott; Severson, Richard K.; Lan, Qing; Brooks-Wilson, Angela; Smith, Martyn T; Roman, Eve; Kricker, Anne; Zhang, Yawei; Kraft, Peter; Chanock, Stephen J.; Rothman, Nathaniel; Hartge, Patricia; Skibola, Christine F.;

Published:

May 07 2018

Source:

Cancer Res. 78(14):4086-4096.

Description:

A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA ...

File Type:

[PDF - 153.36 KB]
A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Personal Author:

Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I; Skibola, Christine F; Slager, Susan L; de Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M; Conde, Lucia; Birmann, Brenda M; Wang, Sophia S; Brooks-Wilson, Angela R; Lan, Qing; de Bakker, Paul I W; Vermeulen, Roel C H; Portlock, Carol; Ansell, Stephen M; Link, Brian K; Riby, Jacques; North, Kari E; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; Becker, Nikolaus; Teras, Lauren R; Spinelli, John J; Turner, Jenny; Zhang, Yawei; Purdue, Mark P; Giles, Graham G; Kelly, Rachel S; Zeleniuch-Jacquotte, Anne; Ennas, Maria Grazia; Monnereau, Alain; Bertrand, Kimberly A; Albanes, Demetrius; Lightfoot, Tracy; Yeager, Meredith; Chung, Charles C; Burdett, Laurie; Hutchinson, Amy; Lawrence, Charles; Montalvan, Rebecca; Liang, Liming; Huang, Jinyan; Ma, Baoshan; Villano, Danylo J; Maria, Ann; Corines, Marina; Thomas, Tinu; Novak, Anne J; Dogan, Ahmet; Liebow, Mark; Thompson, Carrie A; Witzig, Thomas E; Habermann, Thomas M; Weiner, George J; Smith, Martyn T; Holly, Elizabeth A; Jackson, Rebecca D; Tinker, Lesley F; Ye, Yuanqing; Adami, Hans-Olov; Smedby, Karin E; De Roos, Anneclaire J; Hartge, Patricia; Morton, Lindsay M; Severson, Richard K; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Diver, W Ryan; Vajdic, Claire M; Armstrong, Bruce K; Kricker, Anne; Zheng, Tongzhang; Holford, Theodore R; Severi, Gianluca; Vineis, Paolo; Ferri, Giovanni M; Ricco, Rosalia; Miligi, Lucia; Clavel, Jacqueline; Giovannucci, Edward; Kraft, Peter; Virtamo, Jarmo; Smith, Alex; Kane, Eleanor; Roman, Eve; Chiu, Brian C H; Fraumeni, Joseph F; Wu, Xifeng; Cerhan, James R; Offit, Kenneth; Chanock, Stephen J; Rothman, Nathaniel; Nieters, Alexandra;

Published:

Jan 2015

Source:

Nat Commun. 6:5751.

Description:

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 ...

File Type:

[PDF - 518.47 KB]
Report of Public Meeting to Seek Input on Gaps in Chronic Lymphocytic Leukemia (CLL) Radiogenicity Research held July 21, 2004

Corporate Author:

National Institute for Occupational Safety and Health.

Published:

October 2005

Series:

DHHS (NIOSH) publication ; no. (NIOSH) 2006-100

Description:

"Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world. While the etiology of CLL is largely unknown, it is currently the only cancer assigned a probability of causation by ionizing radiation of zero under the US E...

File Type:

[PDF - 505.12 KB]
BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia

Personal Author:

de Smith, Adam J.; Walsh, Kyle M.; Francis, Stephen S.; Zhang, Chenan; Hansen, Helen M.; Smirnov, Ivan; Morimoto, Libby; Whitehead, Todd P.; Kang, Alice; Shao, Xiaorong; Barcellos, Lisa F.; McKean-Cowdin, Roberta; Zhang, Luoping; Fu, Cecilia; Wang, Rong; Yu, Herbert; Hoh, Josephine; Dewan, Andrew T.; Metayer, Catherine; Ma, Xiaomei; Wiemels, Joseph L.;

Published:

Oct 03 2018

Source:

Int J Cancer. 143(11):2647-2658.

Description:

Genome-wide association studies of childhood acute lymphoblastic leukemia (ALL) have identified regions of association at PIP4K2A and upstream of BMI1 at chromosome 10p12.31-12.2. The contribution of both loci to ALL risk and underlying functional va...

Public Access
Available on:

December 01, 2019