Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt, Sonja I.; Camp, Nicola J.; Skibola, Christine F.; Vijai, Joseph; Wang, Zhaoming; Gu, Jian; Nieters, Alexandra; Kelly, Rachel S.; Smedby, Karin E.; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia S.; Lan, Qing; Teras, Lauren R.; Machado, Moara; Yeager, Meredith; Brooks-Wilson, Angela R.; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda M.; Vajdic, Claire M.; Cocco, Pierluigi; Zhang, Yawei; Giles, Graham G.; Zeleniuch-Jacquotte, Anne; Lawrence, Charles; Montalvan, Rebecca; Burdett, Laurie; Hutchinson, Amy; Ye, Yuanqing; Call, Timothy G.; Shanafelt, Tait D.; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Cunningham, Julie M.; Allmer, Cristine; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, Lisa A.; Diver, W Ryan; Link, Brian K.; Weiner, George J.; Conde, Lucia; Bracci, Paige M.; Riby, Jacques; Arnett, Donna K.; Zhi, Degui; Leach, Justin M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Sala, Núria; Casabonne, Delphine; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Chaffee, Kari G.; Achenbach, Sara J.; Vachon, Celine M.; Goldin, Lynn R.; Strom, Sara S.; Leis, Jose F.; Weinberg, J. Brice; Caporaso, Neil E.; Norman, Aaron D.; De Roos, Anneclaire J.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Masala, Giovanna; Weiderpass, Elisabete; Chirlaque, María- Dolores; Vermeulen, Roel C. H.; Travis, Ruth C.; Southey, Melissa C.; Milne, Roger L.; Albanes, Demetrius; Virtamo, Jarmo; Weinstein, Stephanie; Clavel, Jacqueline; Zheng, Tongzhang; Holford, Theodore R.; Villano, Danylo J.; Maria, Ann; Spinelli, John J.; Gascoyne, Randy D.; Connors, Joseph M.; Bertrand, Kimberly A.; Giovannucci, Edward; Kraft, Peter; Kricker, Anne; Turner, Jenny; Ennas, Maria Grazia; Ferri, Giovanni M.; Miligi, Lucia; Liang, Liming; Ma, Baoshan; Huang, Jinyan; Crouch, Simon; Park, Ju-Hyun; Chatterjee, Nilanjan; North, Kari E.; Snowden, John A.; Wright, Josh; Fraumeni, Joseph F.; Offit, Kenneth; Wu, Xifeng; de Sanjose, Silvia; Cerhan, James R.; Chanock, Stephen J.; Rothman, Nathaniel; Slager, Susan L.

doi:10.1038/ncomms10933

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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Mar 09 2016
By Berndt, Sonja I. ; Camp, Nicola J. ; Skibola, Christine F. ; ...
http://dx.doi.org/10.1038/ncomms10933
Source: Nat Commun. 2016; 7.

[PDF-1.02 MB]

English

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Details:

Alternative Title:

Nat Commun
Personal Author:

Berndt, Sonja I. ; Camp, Nicola J. ; Skibola, Christine F. ; Vijai, Joseph ; Wang, Zhaoming ; ... More +

Berndt, Sonja I. ; Camp, Nicola J. ; Skibola, Christine F. ; Vijai, Joseph ; Wang, Zhaoming ; Gu, Jian ; Nieters, Alexandra ; Kelly, Rachel S. ; Smedby, Karin E. ; Monnereau, Alain ; Cozen, Wendy ; Cox, Angela ; Wang, Sophia S. ; Lan, Qing ; Teras, Lauren R. ; Machado, Moara ; Yeager, Meredith ; Brooks-Wilson, Angela R. ; Hartge, Patricia ; Purdue, Mark P. ; Birmann, Brenda M. ; Vajdic, Claire M. ; Cocco, Pierluigi ; Zhang, Yawei ; Giles, Graham G. ; Zeleniuch-Jacquotte, Anne ; Lawrence, Charles ; Montalvan, Rebecca ; Burdett, Laurie ; Hutchinson, Amy ; Ye, Yuanqing ; Call, Timothy G. ; Shanafelt, Tait D. ; Novak, Anne J. ; Kay, Neil E. ; Liebow, Mark ; Cunningham, Julie M. ; Allmer, Cristine ; Hjalgrim, Henrik ; Adami, Hans-Olov ; Melbye, Mads ; Glimelius, Bengt ; Chang, Ellen T. ; Glenn, Martha ; Curtin, Karen ; Cannon-Albright, Lisa A. ; Diver, W Ryan ; Link, Brian K. ; Weiner, George J. ; Conde, Lucia ; Bracci, Paige M. ; Riby, Jacques ; Arnett, Donna K. ; Zhi, Degui ; Leach, Justin M. ; Holly, Elizabeth A. ; Jackson, Rebecca D. ; Tinker, Lesley F. ; Benavente, Yolanda ; Sala, Núria ; Casabonne, Delphine ; Becker, Nikolaus ; Boffetta, Paolo ; Brennan, Paul ; Foretova, Lenka ; Maynadie, Marc ; McKay, James ; Staines, Anthony ; Chaffee, Kari G. ; Achenbach, Sara J. ; Vachon, Celine M. ; Goldin, Lynn R. ; Strom, Sara S. ; Leis, Jose F. ; Weinberg, J. Brice ; Caporaso, Neil E. ; Norman, Aaron D. ; De Roos, Anneclaire J. ; Morton, Lindsay M. ; Severson, Richard K. ; Riboli, Elio ; Vineis, Paolo ; Kaaks, Rudolph ; Masala, Giovanna ; Weiderpass, Elisabete ; Chirlaque, María- Dolores ; Vermeulen, Roel C. H. ; Travis, Ruth C. ; Southey, Melissa C. ; Milne, Roger L. ; Albanes, Demetrius ; Virtamo, Jarmo ; Weinstein, Stephanie ; Clavel, Jacqueline ; Zheng, Tongzhang ; Holford, Theodore R. ; Villano, Danylo J. ; Maria, Ann ; Spinelli, John J. ; Gascoyne, Randy D. ; Connors, Joseph M. ; Bertrand, Kimberly A. ; Giovannucci, Edward ; Kraft, Peter ; Kricker, Anne ; Turner, Jenny ; Ennas, Maria Grazia ; Ferri, Giovanni M. ; Miligi, Lucia ; Liang, Liming ; Ma, Baoshan ; Huang, Jinyan ; Crouch, Simon ; Park, Ju-Hyun ; Chatterjee, Nilanjan ; North, Kari E. ; Snowden, John A. ; Wright, Josh ; Fraumeni, Joseph F. ; Offit, Kenneth ; Wu, Xifeng ; de Sanjose, Silvia ; Cerhan, James R. ; Chanock, Stephen J. ; Rothman, Nathaniel ; Slager, Susan L. Less -
Description:

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
Subjects:

[+]

Adaptor Proteins, Signal Transducing Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Genetic Predisposition To Disease Genome-Wide Association Study Humans Leukemia, Lymphocytic, Chronic, B-Cell Membrane Proteins Polymorphism, Single Nucleotide Proto-Oncogene Proteins Serpins T-Box Domain Proteins White People
Source:

Nat Commun. 2016; 7.
Pubmed ID:

26956414
Pubmed Central ID:

PMC4786871
Document Type:

Journal Article
Funding:

1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; 30 CA086862/CA/NCI NIH HHS/United States ; 5R01 CA69669-02/CA/NCI NIH HHS/United States ; A149445/PHS HHS/United States ; CA098122/CA/NCI NIH HHS/United States ; ... More +

1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; 30 CA086862/CA/NCI NIH HHS/United States ; 5R01 CA69669-02/CA/NCI NIH HHS/United States ; A149445/PHS HHS/United States ; CA098122/CA/NCI NIH HHS/United States ; CA098566/CA/NCI NIH HHS/United States ; CA1046282/CA/NCI NIH HHS/United States ; CA118444/CA/NCI NIH HHS/United States ; CA148690/CA/NCI NIH HHS/United States ; CA149445/CA/NCI NIH HHS/United States ; CA154643/CA/NCI NIH HHS/United States ; CA165923/CA/NCI NIH HHS/United States ; CA167552/CA/NCI NIH HHS/United States ; CA186107/CA/NCI NIH HHS/United States ; CA49449/CA/NCI NIH HHS/United States ; CA62006/CA/NCI NIH HHS/United States ; CA87969/CA/NCI NIH HHS/United States ; CA92153/CA/NCI NIH HHS/United States ; ES000260/ES/NIEHS NIH HHS/United States ; HHSN261201000006C/PHS HHS/United States ; HHSN261201000026C/PHS HHS/United States ; HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000140C/PHS HHS/United States ; HHSN268201100001C/PHS HHS/United States ; HHSN268201100002C/PHS HHS/United States ; HHSN268201100003C/PHS HHS/United States ; HHSN268201100004C/PHS HHS/United States ; HHSN268201100046C/PHS HHS/United States ; HHSN271201100004C/PHS HHS/United States ; K07 CA115687/CA/NCI NIH HHS/United States ; K08CA134919/CA/NCI NIH HHS/United States ; N01-CN-45165/CN/NCI NIH HHS/United States ; N01-PC-65064/PC/NCI NIH HHS/United States ; N01-PC-67008/PC/NCI NIH HHS/United States ; N01-PC-67009/PC/NCI NIH HHS/United States ; N01-PC-67010/PC/NCI NIH HHS/United States ; N01-RC-37004/RC/CCR NIH HHS/United States ; N01-RC-45035/RC/CCR NIH HHS/United States ; N02-PC-71105/PC/NCI NIH HHS/United States ; NIH CA134674/CA/NCI NIH HHS/United States ; P01 CA087969/CA/NCI NIH HHS/United States ; P30 CA008748/CA/NCI NIH HHS/United States ; P30 CA015083/CA/NCI NIH HHS/United States ; P30 CA016087/CA/NCI NIH HHS/United States ; P30 CA15083/CA/NCI NIH HHS/United States ; P30 CA42014/CA/NCI NIH HHS/United States ; P50 CA97274/CA/NCI NIH HHS/United States ; R01 CA049449/CA/NCI NIH HHS/United States ; R01 CA098661/CA/NCI NIH HHS/United States ; R01 CA149445/CA/NCI NIH HHS/United States ; R01 CA92153/CA/NCI NIH HHS/United States ; R35 CA197449/CA/NCI NIH HHS/United States ; U01 HG007033/HG/NHGRI NIH HHS/United States ; UL1 TR000135/TR/NCATS NIH HHS/United States ; UM1 CA167552/CA/NCI NIH HHS/United States ; UM1 CA186107/CA/NCI NIH HHS/United States ; Canadian Institutes of Health Research/Canada ; Cancer Research UK/United Kingdom ; Intramural NIH HHS/United States Less -
Volume:

7
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:eac9b36e08c610bb1dae406a6df1e821ef795636b1225ddb3bd41c00e8711000
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https://stacks.cdc.gov/view/cdc/41035/cdc_41035_DS1.pdf
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