The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes

Details

• Alternative Title:
  Parasit Vectors
• Personal Author:
  Samuel, Michael ; Oliver, Shüné V. ; Coetzee, Maureen ; Brooke, Basil D.
• Description:
  Background
  
  Insecticide resistance carries the potential to undermine the efficacy of insecticide based malaria vector control strategies. Therefore, there is an urgent need for new insecticidal compounds. Black pepper (dried fruit from the vine, Piper nigrum), used as a food additive and spice, and its principal alkaloid piperine, have previously been shown to have larvicidal properties. The aim of this study was to investigate the larvicidal effects of ground black pepper and piperine against third and fourth instar Anopheles larvae drawn from several laboratory-reared insecticide resistant and susceptible strains of Anopheles arabiensis, An. coluzzii, An. gambiae, An. quadriannulatus and An. funestus.
  
  Methods
  
  Larvae were fed with mixtures of standard larval food and either ground black pepper or piperine in different proportions. Mortality was recorded 24 h after black pepper and 48 h after piperine were applied to the larval bowls.
  
  Results
  
  Black pepper and piperine mixtures caused high mortality in the An. gambiae complex strains, with black pepper proving significantly more toxic than piperine. The An. funestus strains were substantially less sensitive to black pepper and piperine which may reflect a marked difference in the feeding habits of this species compared to that of the Gambiae complex or a difference in food metabolism as a consequence of differences in breeding habitat between species.
  
  Conclusions
  
  Insecticide resistant and susceptible strains by species proved equally susceptible to black pepper and piperine. It is concluded that black pepper shows potential as a larvicide for the control of certain malaria vector species.
  
  
• Subjects:
  Alkaloids Animals Anopheles Benzodioxoles Insecticide Resistance Insecticides Larva Malaria Piperidines Piper Nigrum Polyunsaturated Alkamides

  More +
• Source:
  Parasit Vectors. 9.
• Pubmed ID:
  27117913
• Pubmed Central ID:
  PMC4847181
• Document Type:
  Journal Article
• Funding:
  U19 AI089680/AI/NIAID NIH HHS/United States ; U19GH000622-01 MAL01/GH/CGH CDC HHS/United States
• Volume:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0723df7843b81e7a41b50d2b501537e7422e9a8f988c20438e30a4f71ef38f7b
• Download URL:
  https://stacks.cdc.gov/view/cdc/40961/cdc_40961_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]