Genetic basis of irritant susceptibility in health care workers
Published Date:Aug 2016
Source:J Occup Environ Med. 58(8):753-759.
Pubmed Central ID:PMC4980183
Funding:CC999999/Intramural CDC HHS/United States
Y01 S12007001/ES/NIEHS NIH HHS/United States
To investigate the association of single nucleotide polymorphisms (SNPs) within genes involved in inflammation, skin barrier integrity, signaling/pattern recognition and antioxidant defense with irritant susceptibility in a group of health care workers.
Materials and Methods
The 536 volunteer subjects were genotyped for selected SNPs and patch tested with three model irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed on genomic DNA using Illumina Goldengate custom panels.
The ACACB (rs2268387, rs16934132, rs2284685), NTRK2 (rs10868231), NTRK3 (rs1347424), IL22 (rs1179251), PLAU (rs2227564), EGFR (rs6593202) and FGF2 (rs308439) SNPs showed association with skin response to tested irritants in different genetic models (all at p<0.001). Functional annotations identified two SNPs in PLAU (rs2227564) and ACACB (rs2284685) genes with a potential impact on gene regulation. In addition, EGF (rs10029654), EGFR (rs12718939), CXCL12 (rs197452), and VCAM1 (rs3917018) genes showed association with hand dermatitis (p<0.005)
The results demonstrate that genetic variations in genes related to inflammation and skin homeostasis can influence responses to irritants and may explain inter-individual variation in the development of subsequent contact dermatitis.
Supporting Files:No Additional Files
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