Genetic Basis of Irritant Susceptibility in Health Care Workers

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Yucesoy, Berran ; Talzhanov, Yerkebulan ; Barmada, M. Michael ; Johnson, Victor J. ; Kashon, Michael L. ; Baron, Elma ; Wilson, Nevin W. ; Frye, Bonnie ; Wang, Wei ; Fluharty, Kara ; Gharib, Rola ; Meade, Jean ; Germolec, Dori ; Luster, Michael I. ; Nedorost, Susan
• Description:
  Objective
  
  To investigate the association of single nucleotide polymorphisms (SNPs) within genes involved in inflammation, skin barrier integrity, signaling/pattern recognition and antioxidant defense with irritant susceptibility in a group of health care workers.
  
  Materials and Methods
  
  The 536 volunteer subjects were genotyped for selected SNPs and patch tested with three model irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed on genomic DNA using Illumina Goldengate custom panels.
  
  Results
  
  The ACACB (rs2268387, rs16934132, rs2284685), NTRK2 (rs10868231), NTRK3 (rs1347424), IL22 (rs1179251), PLAU (rs2227564), EGFR (rs6593202) and FGF2 (rs308439) SNPs showed association with skin response to tested irritants in different genetic models (all at p<0.001). Functional annotations identified two SNPs in PLAU (rs2227564) and ACACB (rs2284685) genes with a potential impact on gene regulation. In addition, EGF (rs10029654), EGFR (rs12718939), CXCL12 (rs197452), and VCAM1 (rs3917018) genes showed association with hand dermatitis (p<0.005)
  
  Conclusions
  
  The results demonstrate that genetic variations in genes related to inflammation and skin homeostasis can influence responses to irritants and may explain inter-individual variation in the development of subsequent contact dermatitis.
  
  
• Subjects:
  Adolescent Adult Aged Benzalkonium Compounds Dermatitis, Contact Female Genotype Health Personnel Humans Irritants Male Middle Aged Patch Tests Polymorphism, Single Nucleotid Sodium Dodecyl Sulfate Sodium Hydroxide Young Adult

  More +
• Source:
  J Occup Environ Med. 58(8):753-759.
• Pubmed ID:
  27206134
• Pubmed Central ID:
  PMC4980183
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; Y01 S12007001/ES/NIEHS NIH HHS/United States
• Volume:
  58
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:613e8decf37acf1ff0e978c2a125b8e55ce52a727611ca0fb8f0090b2d5ede17
• Download URL:
  https://stacks.cdc.gov/view/cdc/40887/cdc_40887_DS1.pdf
• File Type:
  [PDF - 359.30 KB ]