Details:

Alternative Title:
J Occup Environ Med
Personal Author:
Yucesoy, Berran ; Talzhanov, Yerkebulan ; Barmada, M. Michael ; Johnson, Victor J. ; Kashon, Michael L. ; ... More +
Yucesoy, Berran ; Talzhanov, Yerkebulan ; Barmada, M. Michael ; Johnson, Victor J. ; Kashon, Michael L. ; Baron, Elma ; Wilson, Nevin W. ; Frye, Bonnie ; Wang, Wei ; Fluharty, Kara ; Gharib, Rola ; Meade, Jean ; Germolec, Dori ; Luster, Michael I. ; Nedorost, Susan Less -
Description:
Objective

To investigate the association of single nucleotide polymorphisms (SNPs) within genes involved in inflammation, skin barrier integrity, signaling/pattern recognition and antioxidant defense with irritant susceptibility in a group of health care workers.

Materials and Methods

The 536 volunteer subjects were genotyped for selected SNPs and patch tested with three model irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed on genomic DNA using Illumina Goldengate custom panels.

Results

The ACACB (rs2268387, rs16934132, rs2284685), NTRK2 (rs10868231), NTRK3 (rs1347424), IL22 (rs1179251), PLAU (rs2227564), EGFR (rs6593202) and FGF2 (rs308439) SNPs showed association with skin response to tested irritants in different genetic models (all at p<0.001). Functional annotations identified two SNPs in PLAU (rs2227564) and ACACB (rs2284685) genes with a potential impact on gene regulation. In addition, EGF (rs10029654), EGFR (rs12718939), CXCL12 (rs197452), and VCAM1 (rs3917018) genes showed association with hand dermatitis (p<0.005)

Conclusions

The results demonstrate that genetic variations in genes related to inflammation and skin homeostasis can influence responses to irritants and may explain inter-individual variation in the development of subsequent contact dermatitis.


Subjects:
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Article Genetics Health Care Workers Irritant Contact Dermatitis
Source:
J Occup Environ Med. 58(8):753-759.
Pubmed ID:
27206134
Pubmed Central ID:
PMC4980183
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; Y01 S12007001/ES/NIEHS NIH HHS/United States
CC999999/Intramural CDC HHS/United States ; Y01 S12007001/ES/NIEHS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:613e8decf37acf1ff0e978c2a125b8e55ce52a727611ca0fb8f0090b2d5ede17
Download URL:
https://stacks.cdc.gov/view/cdc/40887/cdc_40887_DS1.pdf
File Type:

Supporting Files

• 	nihms-783605.nxml	bin
  	NIHMS783605-supplement-Supplemental_Digital_Content.doc	doc

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