Probable Rabies Virus Transmission through Organ Transplantation, China, 2015

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Zhou, Hang ; Zhu, Wuyang ; Zeng, Jun ; He, Jianfeng ; Liu, Kai ; Li, Yu ; Zhou, Shuwu ; Mu, Di ; Zhang, Kechun ; Yu, Pengcheng ; Li, Zhijian ; Zhang, Meng ; Chen, Xueqiong ; Guo, Chun ; Yu, Hongjie
• Description:
  During July 2015, physicians at a hospital in Beijing, China, diagnosed rabies in 2 patients who had each received a kidney from a common organ donor who had died from acute progressive encephalitis of unknown cause. The patients had rabies incubation periods of 42 and 48 days. Altered mental status developed in both patients and progressively worsened to deep coma within 80 days after transplantation; both patients died. Two other transplant recipients received corneas but remained well after receiving timely rabies prophylaxis. An effective regulatory system for testing donors should be implemented to decrease the occurrence of donor-derived infectious diseases. In addition, health education should be improved to enhance public awareness of transplant-associated infectious diseases. Transplant recipients and other persons with exposure to organs or tissues from donors with rabies must be provided consistent health monitoring and follow-up, including rabies postexposure prophylaxis; any remaining organs and tissues must be quarantined and not transplanted.
• Subjects:
  Adult Child Corneal Transplantation Humans Infectious Disease Incubation Period Kidney Transplantation Male Middle Aged Rabies/transmission Rabies/virology Rabies Virus Synopsis Tissue Donors Transplant-associated Transmission

  More +
• Source:
  Emerg Infect Dis. 22(8):1348-1352.
• Pubmed ID:
  27331337
• Pubmed Central ID:
  PMC4982156
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  22
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a6bea7dc07b2caba68656e3a138d0e147a4a6a422e13603cac4ae4abc6e8b7d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/40860/cdc_40860_DS1.pdf
• File Type:
  [PDF - 710.07 KB ]