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Military Service, Deployments, and Exposures in Relation to Amyotrophic Lateral Sclerosis Etiology
  • Published Date:
    Feb 23 2016
  • Source:
    Environ Int. 91:104-115.

Public Access Version Available on: May 01, 2017 information icon
Please check back on the date listed above.
  • Pubmed ID:
  • Pubmed Central ID:
  • Funding:
    R01 ES13244/ES/NIEHS NIH HHS/United States
    T32ES007018/ES/NIEHS NIH HHS/United States
    T42OH00867302/OH/NIOSH CDC HHS/United States
    Z01 ES049005/ES/NIEHS NIH HHS/United States
    Z01 ES049005-16/Intramural NIH HHS/United States
  • Document Type:
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  • Description:

    Factors underlying a possible excess of amyotrophic lateral sclerosis (ALS) among military veterans remain unidentified. Limitations of previous studies on this topic include reliance on ALS mortality as a surrogate for ALS incidence, low statistical power, and sparse information on military-related factors.


    We evaluated associations between military-related factors and ALS using data from a case-control study of U.S. military veterans.


    From 2005 to 2010, we identified medical record-confirmed ALS cases via the National Registry of Veterans with ALS and controls via the Veterans Benefits Administration’s Beneficiary Identification and Records Locator System database. In total, we enrolled 621 cases and 958 frequency-matched controls in the Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis study. We collected information on military service and deployments and 39 related exposures. We used unconditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). We used inverse probability weighting to adjust for potential bias from confounding, missing covariate data, and selection arising from a case group that disproportionately included long-term survivors and a control group that may or may not differ from U.S. military veterans at large.


    The odds of ALS did not differ for veterans of the Air Force, Army, Marines, and Navy. We found higher odds of ALS for veterans whose longest deployment was World War II or the Korean War and a positive trend with total years of all deployments (OR = 1.27; 95% CI: 1.06, 1.52). ALS was positively associated with exposure to herbicides for military purposes, nasopharyngeal radium, personal pesticides, exhaust from heaters or generators, high-intensity radar waves, contaminated food, explosions within one mile, herbicides in the field, mixing and application of burning agents, burning agents in the field, and Agent Orange in the field, with ORs between 1.50 and 7.75.


    Although our results need confirmation, they are potentially important given the large number of U.S. military veterans, and they provide clues to potential factors underlying the apparent increase of ALS in veteran populations.

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