Family history and the natural history of colorectal cancer: systematic review

Details

• Alternative Title:
  Genet Med
• Personal Author:
  Henrikson, Nora B. ; Webber, Elizabeth M. ; Goddard, Katrina A. ; Scrol, Aaron ; Piper, Margaret ; Williams, Marc S. ; Zallen, Doris T. ; Calonge, Ned ; Ganiats, Theodore G. ; Janssens, A. Cecile J.W. ; Zauber, Ann ; Lansdorp-Vogelaar, Iris ; van Ballegooijen, Marjolein ; Whitlock, Evelyn P.
  More +
• Description:
  Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks.|We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening.|We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC.|Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history-based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.
• Subjects:
  • Colorectal Neoplasms
  • Early Detection of Cancer
  • Family Health
  • Genetic Predisposition to Disease
  • Humans
  • Prevalence
  • Risk Factors
• Keywords:
  • Family history
  • risk stratification
  • colorectal cancer
  • systematic review
• Source:
  Genet Med. 17(9):702-712
• Pubmed ID:
  25590981
• Pubmed Central ID:
  PMC4955831
• Document Type:
  Text
• Funding:
  P30 CA008748/CA/NCI NIH HHSUnited States/ ; U18 GD000076/GD/OGDP CDC HHSUnited States/ ; 5U18GD000076-02/GD/OGDP CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  17
• Issue:
  9
• Download URL:
  https://stacks.cdc.gov/view/cdc/40426/cdc_40426_DS1.pdf
• File Type:
  [PDF - 218.44 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f289951301a941481536513a0d9384ddb81cdebce79c659558d2794a0e547eb097468acf18b1da7d1eeb219af483940c089556dd9b53919b51af674589898ed4