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Multi-elemental bio-imaging of tissues in children's environmental health research
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  • Description:
    Purpose of review

    Metals play major roles in children's health and are associated with negative health outcomes via deficiency, overload or toxicity. Constantly evolving analytical technology can provide new insight into how metal metabolism and exposure biology are intertwined in a range of biological matrices.

    Recent findings

    Exposure can occur prenatally as many metals cross the placental barrier. The placenta is permeable to many metal species, some through tightly regulated transporters, and others because of a limited capacity for detoxification. Post-birth, metal exposure continues to exert long-term health effects, ranging from exposure to exogenous heavy metals, such as lead, to overload of otherwise essential metals, including manganese. Increasing evidence supports the existence of critical developmental windows when susceptibility to toxicants and nutritional deficiencies is highest. Elemental imaging technology provides micro-spatial information on metal uptake and retention across tissue architecture, which provides important insights into exposure and biologic response.


    Imaging the spatial distribution of elements, both essential and toxic, provides information that bulk measures cannot, including cell-specific distributions and timing of exposure.

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  • Funding:
    DP2 ES025453/ES/NIEHS NIH HHS/United States
    R00 ES019597/ES/NIEHS NIH HHS/United States
    DP2ES025453/DP/NCCDPHP CDC HHS/United States
    R00ES019597/ES/NIEHS NIH HHS/United States
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