Details:

Alternative Title:
Curr Opin Pediatr
Publisher's site:
http://dx.doi.org/10.1097/MOP.0000000000000328
Personal Author:
Austinc, Christine ; Niedzwiecki, Megan M. ; Arora, Manish ;
Austinc, Christine ; Niedzwiecki, Megan M. ; Arora, Manish ; Less -
Description:
Purpose of review Metals play major roles in children's health and are associated with negative health outcomes via deficiency, overload or toxicity. Constantly evolving analytical technology can provide new insight into how metal metabolism and exposure biology are intertwined in a range of biological matrices. Recent findings Exposure can occur prenatally as many metals cross the placental barrier. The placenta is permeable to many metal species, some through tightly regulated transporters, and others because of a limited capacity for detoxification. Post-birth, metal exposure continues to exert long-term health effects, ranging from exposure to exogenous heavy metals, such as lead, to overload of otherwise essential metals, including manganese. Increasing evidence supports the existence of critical developmental windows when susceptibility to toxicants and nutritional deficiencies is highest. Elemental imaging technology provides micro-spatial information on metal uptake and retention across tissue architecture, which provides important insights into exposure and biologic response. Summary Imaging the spatial distribution of elements, both essential and toxic, provides information that bulk measures cannot, including cell-specific distributions and timing of exposure.
Subject:
[+]
Article
Elemental Imaging
Environmental Exposure
Environmental Health
Environmental Pollutants
Female
Humans
Maternal-Fetal Exchange
Metals
Metals, Heavy
Placenta
Pregnancy
Prenatal Exposure Delayed Effects

Source:
Curr Opin Pediatr. 28(2):216-220
Pubmed ID:
26845145
Pubmed Central ID:
PMC4949600
Document Type:
Journal Article ;
Funding:
DP2 ES025453/ES/NIEHS NIH HHS/United States ; R00 ES019597/ES/NIEHS NIH HHS/United States ; DP2ES025453/DP/NCCDPHP CDC HHS/United States ; R00ES019597/ES/NIEHS NIH HHS/United States ;
DP2 ES025453/ES/NIEHS NIH HHS/United States ; R00 ES019597/ES/NIEHS NIH HHS/United States ; DP2ES025453/DP/NCCDPHP CDC HHS/United States ; R00ES019597/ES/NIEHS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:af75172e5b1a097fbfcb7f86787fb614915c01a8ef95eb74f3fd846b9059aa02
File Type:

Supporting Files

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